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Inhibitory Effects of an Antioxidant Coating on a Polylactic Acid Film on Inflammatory Cytokines from Macrophage

Title
Inhibitory Effects of an Antioxidant Coating on a Polylactic Acid Film on Inflammatory Cytokines from Macrophage
Translated Title
Inhibitory Effects of an Antioxidant Coating on a Polylactic Acid Film on Inflammatory Cytokines from Macrophage
Authors
Lee, Ga HyunLee, Sung JuneJeong, Sang WonKim, Hyun-ChulChoi, Jin HyunLee, Se Geun
DGIST Authors
Lee, Sung JuneJeong, Sang WonKim, Hyun-ChulLee, Se Geun
Issue Date
2015-11
Citation
Polymer: Korea, 39(6), 934-939
Type
Article
Article Type
Article
Keywords
Anti-InflammatoryAntioxidantControlled ReleaseImplantationPLA Film
ISSN
0379-153X
Abstract
Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films. © 2015 The Polymer Society of Korea. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/5158
DOI
10.7317/pk.2015.39.6.934
Publisher
Polymer Society of Korea
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles


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