Cited 13 time in webofscience Cited 16 time in scopus

Thiol-responsive gemini poly(ethylene glycol)-poly(lactide) with a cystine disulfide spacer as an intracellular drug delivery nanocarrier

Title
Thiol-responsive gemini poly(ethylene glycol)-poly(lactide) with a cystine disulfide spacer as an intracellular drug delivery nanocarrier
Authors
Kim, Hyun-ChulKim, EunjooHa, Tae-LinJeong, Sang WonLee, Se GuenLee, Sung JunLee, Boram
DGIST Authors
Kim, Hyun-ChulKim, EunjooJeong, Sang WonLee, Se GuenLee, Sung Jun
Issue Date
2015-03-01
Citation
Colloids and Surfaces B: Biointerfaces, 127, 206-212
Type
Article
Article Type
Article
Keywords
Antineoplastic ActivityBiodegradabilityBiodegradableBiodegradable PolymersCell CultureCell Line, TumorCell ProliferationCell SurvivalCell TransportCell ViabilityChemistryChromatography, GelConfocal Laser MicroscopyControlled Drug DeliveryControlled StudyCystineCystinesCytotoxicityDisulfideDisulfide-Thiol ExchangeDisulfide-Thiol ExchangesDisulfidesDoxorubicinDrug CarrierDrug CarriersDrug DeliveryDrug Delivery SystemDrug Delivery SystemsDrug EffectsDrug EfficacyEnzyme InhibitionGel Permeation ChromatographyGemini SurfactantGemini SurfactantsGlutathioneHumanHuman CellHumansHydrophilicityHydrophobicityLight ScatteringMacrogolMacrogol DerivativeMicelleMicellesMicellizationNano-CarrierNanoparticleNanoparticlesParticle SizePoly(Ethyleneglycol-Lactide)PolyesterPolyestersPolyethylene GlycolsPolylactidePolymerizationPolymersPolyolsSize Exclusion ChromatographyStimulus-Sensitive PolymersSulfhydryl CompoundsSulfur CompoundsSynthesisThiol DerivativeTumor Cell LineUltrastructure
ISSN
0927-7765
Abstract
Thiol-responsive gemini micelles consisting of hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic polylactide (PLA) blocks with a cystine disulfide spacer were reported as effective intracellular nanocarriers of drugs. In the presence of cellular glutathione (GSH) as a reducing agent, gemini micelles gradually destabilize into monomeric micelles through cleavage of the cystine linkage. This destabilization of the gemini micelles changed their size distribution, with the appearance of small aggregates, and led to the enhanced release of encapsulated doxorubicin (DOX). The results obtained from cell culture via confocal laser scanning microscopy (CLSM) for cellular uptake, as well as cell viability measurements for anticancer efficacy suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers. © 2015 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/5200
DOI
10.1016/j.colsurfb.2015.01.039
Publisher
Elsevier B.V.
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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