Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kang, Chan Woo | - |
dc.contributor.author | Han, Ye Eon | - |
dc.contributor.author | Lee, Mi Kyung | - |
dc.contributor.author | Cho, Yoon Hee | - |
dc.contributor.author | Kang, Na Na | - |
dc.contributor.author | Koo, Jae Hyung | - |
dc.contributor.author | Ku, Cheol Ryong | - |
dc.contributor.author | Lee, Eun Jig | - |
dc.date.accessioned | 2018-05-02T00:12:52Z | - |
dc.date.available | 2018-05-02T00:12:52Z | - |
dc.date.created | 2018-04-30 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6249 | - |
dc.description.abstract | Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secretion via extracellular signal-regulated kinase (ERK)1/2 signaling. Real-time PCR analysis and the Ca2+ influx assay revealed that OMP was critical for TRH-induced PRL secretion. OMP-knockout mice showed lower fertility than control mice, which was associated with increased basal PRL production via activation of ERK1/2 signaling and reduced TRH-induced PRL secretion. However, both in vitro and in vivo results indicated that OMP was only required for hormone production and secretion because ERK1/2 activation failed to stimulate cell proliferation. Additionally, patients with prolactinoma lacked OMP expression in tumor tissues with hyperactivated ERK1/2 signaling. These findings indicate that OMP plays a role in PRL production and secretion in lactotrophs through the modulation of Ca2+ and TRH signaling. © 2018 The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s12276-018-0035-z | - |
dc.identifier.scopusid | 2-s2.0-85045096918 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, v.50, no.4, pp.1 - 11 | - |
dc.identifier.kciid | ART002342553 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | THYROTROPIN-RELEASING-HORMONE | - |
dc.subject.keywordPlus | VECTOR-MEDIATED RESCUE | - |
dc.subject.keywordPlus | PITUITARY-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NEUROENDOCRINE CARCINOMAS | - |
dc.subject.keywordPlus | ADENYLYL-CYCLASE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | OMP | - |
dc.subject.keywordPlus | KINASE | - |
dc.citation.endPage | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.volume | 50 | - |