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ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes

  • Lee, Hyein ; 
  • Cho, Sukhee ; 
  • Kim, Mi-Jin ; 
  • Park, Yeo Jin ; 
  • Cho, Eunji ; 
  • Jo, Yeon Suk ; 
  • Kim, Yong-Seok ; 
  • Lee, Jung Yi ; 
  • Thoudam, Themis ; 
  • Woo, Seung-Hwa ; 
  • et al
  • 2023-10
  • Lee, Hyein. (2023-10). ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes. Cell Reports, 42(10). doi: 10.1016/j.celrep.2023.113183
  • Cell Press
  • View : 549
  • Download : 120

Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4

  • Lee, Se-In ; 
  • Yu, Jichang ; 
  • Lee, Hyein ; 
  • Kim, Buyun ; 
  • Jang, Min Jun ; 
  • Jo, Hyeonbin ; 
  • Kim, Na Yeon ; 
  • Pak, Malk Eun ; 
  • Kim, Jae Kwang ; 
  • Cho, Sukhee ; 
  • et al
  • 2025-08
  • Nature Communications, v.16, no.1
  • Nature Publishing Group
  • View : 248
  • Download : 157
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