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LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons
LAMP1 and LAMP2A (an isoform of LAMP2) are abundant proteins of late endosomal/lysosomal compartments that are often used interchangeably to label what is assumed to be the same organelle population, potentially obscuring distinct physiological roles. Here, we characterised the axonal transport dynamics of LAMP1-and LAMP2A-positive compartments in human induced pluripotent stem cell (hiPSC)-derived cortical neurons. We found that LAMP1-positive organelles move slower in the retrograde direction,
2026-02
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TENG-Driven Electrotherapy: A Self-Powered Approach to Inducing Cancer Cell Apoptosis
Most of the cancer-related deaths are caused by metastasis, which also remains a significant obstacle to successful clinical management. Even though several anti-metastatic treatments have been put forth, systemic toxicity, low cellular responsiveness, and drug resistance typically undermine their therapeutic efficacy. Although triboelectric nanogenerators (TENGs) have become highly effective self-powered electrical therapies for biomedical applications, their potential as an active treatment to
2026-07
SITI-Wrap: Secure Integrity for Third-Party IOMMUs
As general-purpose processors continue to face scaling limitations, system-on-chip (SoC) designs grow in popularity due to their lower power consumption and smaller space complexity. For more flexible SoC designs, primary SoC manufacturers incorporate third-party intellectual property (IP) to satisfy system needs, leading to higher modularity. However, reliance on third-party IPs compromises the overall security of the design, as manufacturers can no longer fully guarantee its integrity. To prot
2026-09
Red-Light-Absorbing Donor-Acceptor Conjugated Polymer Nanoparticles Enable Efficient and Biocompatible Photobiocatalysis
Redox enzymes offer high selectivity in chemical transformations, but their practical applications require continuous regeneration of expensive and unstable redox cofactors. Photocatalytic cofactor regeneration has shown promise as an efficient and sustainable strategy. However, most reported systems rely on ultraviolet or blue-light excitation, frequently leading to photodamage and enzyme deactivation. Here, we report a red-light-driven photobiocatalytic platform based on well-dispersible nanop
2026-08
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Applications of flexible and stretchable three-dimensional structures for soft electronics
The development of devices that can be mechanically deformed in geometrical layouts, such as flexible/stretchable devices, is important for various applications. Conventional flexible/stretchable devices have been demonstrated using two-dimensional (2D) geometry, resulting in dimensional constraints on device operations and functionality limitations. Accordingly, expanding the dimensions in which such devices can operate and acquiring unique functionality that is difficult to implement in 2D pla
2023-06
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Precise Synchronization Between LiDAR and Multiple Cameras for Autonomous Driving: An Adaptive Approach
LiDAR and camera are crucial perception sensors that provide complementary information for object detection in autonomous driving vehicles. However, the fusion of sensor data to achieve efficient object detection requires accurate calibration and precise time synchronization between the sensors. While calibration ensures the geometric relationship between the sensors, and time synchronization ensures that data from both sensors corresponds to the same moment in the real world. Even though variou
2025-03
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Recent Advances in Ultra-High-Speed Wireline Receivers with ADC-DSP-Based Equalizers
High-speed wireline data transceivers (TRX) with analog-to-digital converter (ADC) followed by digital signal processor (DSP) on the receiver (RX) equalizer became popular for applications requiring >100 Gb/s per-lane data rate over long-reach (LR) channels, especially for datacenter applications. With the digital-to-analog converter (DAC)-based transmitter (TX) including DSP-based TX signal processing, the overall structure of DAC/ADC-DSP-based wireline TRXs became similar to modulator/demodula
2024-11
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Edge-Server Workload Characterization in Vehicular Computation Offloading: Semantics and Empirical Analysis
Edge server-assisted computation offloading enables vehicles to leverage server compute resources to deliver connected services, overcoming the limitations of onboard resources. Understanding the compute workloads of edge servers is crucial for effective resource management and scheduling, yet this task is challenging due to the complex interplay of factors such as vehicle mobility and computation offloading patterns. To address this, we propose an empirical analysis framework that systematicall
2024-06
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