Engineering of tandem bispecific IL-7 receptor agonist antibody promoting selective T cell expansion
Park, Jun-Kook
;
Jung, Inseong
;
Lee, Seunghyun
;
Kim, Jisuk
;
Shin, Sanghee
;
Shin, Jiwon
;
Noh, Soojeong
;
Kwon, Dahye
;
Nam, Chaerin
;
Kim, Hyunwook
;
Choi, Hongsoo
;
Yea, Kyungmoo
Interleukin-7 (IL-7) is indispensable for T cell development and homeostasis, and clinical studies have demonstrated its ability to restore T cell numbers in lymphopenic conditions. However, the therapeutic application of IL-7 has been limited by its short half-life and potential immunogenicity of recombinant variants. To overcome these challenges, we engineered a fully human tandem bispecific antibody, TB4, that functions as a potent IL-7 receptor agonist by cis-targeting IL-7 receptor alpha (I