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Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma
Background Mutations in isocitrate dehydrogenase 1 (IDH1) are hallmark features of diffuse gliomas and drive extensive metabolic and epigenetic reprogramming through accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). However, the downstream transcriptional programs and chromatin-based mechanisms linking mutant IDH1 to oncogenic signaling remain incompletely understood. Objective This study aimed to define transcriptional changes associated with the IDH1 R132H mutation and to determine
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In Silico Prediction of EZHIP Post-Translational Modification Sites and Small-Molecule High-Throughput Screening for Quantitative EZHIP Modulation
Background Posterior fossa group A (PFA) ependymoma is a lethal pediatric brain tumor driven predominantly by epigenetic dysregulation. Enhancer of Zeste Homologs Inhibitory Protein (EZHIP) is a defining oncogenic factor in PFA ependymoma that inhibits PRC2 activity, inducing a global loss of H3K27me3 and sustaining aberrant developmental transcriptional programs. Although the metabolic modulator, metformin, reduces EZHIP protein levels, the mechanisms governing EZHIP regulation remain undefined
2026-04
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Closed-crown packaging system for stable, long-term neural recording in group-housed mice
Long-term recording of neural circuit activity in behaving mice is essential for understanding the pathophysiology of neuropsychiatric disorders and developing effective therapies. However, conventional open-crown packaging leaves cables and connectors exposed, making them vulnerable to biting, mechanical impact, and contamination. In group-housing conditions, these weaknesses often cause cable disconnection or probe damage, forcing single housing and undermining the ecological validity of studi
2026-05
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Progress in ionomer-based microenvironment engineering of gas diffusion electrodes for electrochemical CO2 reduction
The electrochemical CO2 reduction reaction (CO2RR) has emerged as a promising pathway toward net-zero emissions and carbon neutrality. For efficient CO2RR, optimizing the microenvironment of catalysts in the gas diffusion electrode (GDE) system is essential. Ionomer, composed of hydrophobic polymer chains and hydrophilic ionic groups, can be utilized to optimize the CO2 mass transfer and surface properties of catalyst layers in GDE. This review highlights the effect of ionomers on microenvironme
2026-04
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How to Use Library E-Resources Effectively
A manual guides you on searching, browsing, analyzing, and managing references using library resources and free search engines.
1) It deals with the differences, features, and usage of databases for searching journal articles such as Web of Science, SCOPUS, and Google Scholar.
2) It introduces JCR and Journal Impact Factor(JIF), which search for journal information and rankings.
3) It deals with managing references using reference tools such as EndNote and Mendeley.
4) A list
1) It deals with the differences, features, and usage of databases for searching journal articles such as Web of Science, SCOPUS, and Google Scholar.
2) It introduces JCR and Journal Impact Factor(JIF), which search for journal information and rankings.
3) It deals with managing references using reference tools such as EndNote and Mendeley.
4) A list
2022-07-12
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바이오 응용을 위한 초음파 및 광학 기반 다중 모달 영상 기술
이 연구는 초음파 광학 영상 기반의 다중 모달 영상 기술에 대한 최신 연구 동향과 응용 가능성에 대해 조사하였다. 초음파 영상은 실시간 영상 기능을 가지고 있으며 인체에 상대적으로 안전한 특성으로 인해 의료 분야에서 다양한질병의 진단에 사용되고 있다. 그러나 초음파 영상은 해상도가 낮은 한계가 있어 진단 정확도를 향상시키기 위해 다른광학 영상과의 결합을 통한 다중 모달 영상 기술 개발 연구가 진행되고 있다. 특히 초음파 광학 영상 기반의 다중 모달영상 기술은 각각의 영상 기법의 장점을 극대화하고 단점을 보완함으로써 질병 진단 정확도를 향상시킬 수 있는 수단으로 사용되고 있다. 이러한 기술은 초음파의 실시간 영상 기능과 광간섭 단층 영상 융합 기술, 초음파 광음향 다중 모달영상 기술, 초음파 형광 다중 모달 영상 기술, 초음파 형광 시정수 다중 모달 영상 기술 및 초음파 분광 다중 모달 영상기술 등 다양한 형태로 제안되고 있다. 본 연구에서는 이러한 초음파 광학 영상 기반의 다중 모달
2023-09
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Applications of flexible and stretchable three-dimensional structures for soft electronics
The development of devices that can be mechanically deformed in geometrical layouts, such as flexible/stretchable devices, is important for various applications. Conventional flexible/stretchable devices have been demonstrated using two-dimensional (2D) geometry, resulting in dimensional constraints on device operations and functionality limitations. Accordingly, expanding the dimensions in which such devices can operate and acquiring unique functionality that is difficult to implement in 2D pla
2023-06
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Signal Processing Design for Cochlear Implant System Using Piezoelectric Sensor
Today, the cochlear implant system is the most successful auditory prosthesis for the patients suffering hair cell loss or damage. The current cochlear implant system consists of an implantable electrode array for the stimulation and an external signal processor includ-ing a microphone and a battery. However, the conventional cochlear implant system is composed of a heavy signal processor. Furthermore, the exposure of an external signal processor causes a cosmetic problem to the patients. Theref
2014
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