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TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity
Ion channels are essential for sensing somatic stimuli, and their dysregulation can cause chronic conditions such as neuropathic pain. Although the potassium channel Twik-1 has been linked to sensory processing, its specific roles in the somatosensory system under normal and disease conditions remain unclear. Here, we demonstrate that systemic deletion of Twik-1 selectively reduces innocuous tactile and noxious mechanosensation evoked by both static and dynamic mechanical stimuli and facilitates
2026-06
High-purity defect-engineered porous carbons from cellulose amorphization and steam activation for one-million-cycle supercapacitor durability
In this study, we propose a crystallinity-engineering strategy for developing high-purity activated carbon (AC) with a hierarchical pore structure for high-performance supercapacitor electrodes. Our results demonstrate that the precursor's amorphization is critical in determining the activation efficiency and the defect density of the resultant AC materials. By combining ultrasonic-assisted amorphization of cellulose with hydrothermal purification, activation efficiency was significantly enhance
2026-05
Kinetic origin and mitigation of sudden capacity fade in silicon-based lithium-ion batteries
Silicon (Si)-based full cells maintain stable cycling at elevated temperatures yet exhibit a sudden capacity fade at room temperature. This temperature-dependent behavior is specific to Si-based full cells and cannot be explained by conventional graphite-based degradation models. This study identifies the origin of the fade mechanism as a Si-intrinsic, kinetics-driven degradation process and proposes a corresponding mitigation strategy. Electrochemical and post-mortem analyses show that intrinsi
2026-06
Social Reasoning-Aware Trajectory Prediction via Multimodal Language Model
Recent advancements in language models have demonstrated its capacity of context understanding and generative representations. Leveraged by these developments, we propose a novel multimodal trajectory predictor based on a vision-language model, named VLMTraj, which fully takes advantage of the prior knowledge of multimodal large language models and the human-like reasoning across diverse modality information. The key idea of our model is to reframe the trajectory prediction task into a visual qu
2026-06
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Modeling and Precision Stop of Metropolitan Train with Receding Horizon Control
Modeling of new type of metropolitan train, which is to be introduced on Korean railways in near future, and the control strategy for precision stop is tested in simulation. Modeling is carried out based on the raw test data and previously measured specifications provided by the Korean Railroad Research Institute. Control strategy is divided to two stages. Feed-forward and PI controller was implemented for initial stage. The controller is then switched to a Linear Receding Horizon Controller clo
2015
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A Power-Efficient μ-Heater Driving Circuit for Gas Sensor
Metal-oxide-semiconductor gas sensor consists of sensing layer detecting exposed gases and micro heater generating heat necessary for achieving the best performance of gas reaction. For gas sensor to get high sensitivity, optimal temperature of micro heater should be supplied to sensing layer. In addition, optimal temperature range of each micro heater has different characteristics based on sensing materials and target gases, which needs a demand for designing micro heater driving system. As a s
2017
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Recent Advances in Ultra-High-Speed Wireline Receivers with ADC-DSP-Based Equalizers
High-speed wireline data transceivers (TRX) with analog-to-digital converter (ADC) followed by digital signal processor (DSP) on the receiver (RX) equalizer became popular for applications requiring >100 Gb/s per-lane data rate over long-reach (LR) channels, especially for datacenter applications. With the digital-to-analog converter (DAC)-based transmitter (TX) including DSP-based TX signal processing, the overall structure of DAC/ADC-DSP-based wireline TRXs became similar to modulator/demodula
2024-11
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Characterization of the interaction between Parkin and TSPO-VDAC complex in mediating immune responses in Drosophila
Parkin, an E3 ubuquitin ligase associated with Parkinson's disease (PD), has recently been implicated in mediating innate immunity. However, molecular details regarding parkin-mediated immune response remain to be elucidated. Here, we identified mitochondrial TSPO-VDAC complex to genetically interact with parkin in mediating responses against infection and wound in Drosophila. The loss-of-function mutation in parkin results in defective immune response against bacterial infection. Additionally,
2016
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