Polystyrene Nanoplastics Exacerbate CCl4-Induced Liver Fibrosis by Aggravating Stretch-Induced Mechanical Stress in Hepatic Stellate Cells
Yim, Jae-Hyuk
;
Kim, Tae-Un
;
Kim, Woo Jun
;
Kim, Hee-Yeon
;
Lee, Seoung-Woo
;
Kang, Kyung-Ku
;
Seo, Min-Soo
;
Kim, Sung Dae
;
Cho, Young-Eun
;
Baek, Su-Min
;
Choi, Seong-Kyoon
;
Park, Jin-Kyu
Although studies on the potential hepatotoxicity of nanoplastic depositions are being conducted, there remains a lack of research on the association between nanoplastic depositions and chronic liver disease. Therefore, this research aimed to explore the influence of polystyrene nanoparticles (PS-NPs) on the progression of liver fibrosis and the mechanisms involved in the hepatic stellate cells (HSCs) activation. Chronic exposure to PS-NPs aggravated CCl4-induced liver fibrosis, as evidenced by e