Down-regulation of HSPA9 reduces tyrosine hydroxylase-positive neurons in mouse substantia nigra and induces Parkinson's disease-like motor impairments
Hyung, Hyejin
;
Jang, Soyoung
;
Kim, Si-Yong
;
Bae, Ji-Eun
;
Park, Ji Yeong
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Lim, Su-Geun
;
Ko, Jiwon
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Jang, Soyeon
;
Kim, Joon Bum
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Chae, Hee Young
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Park, Song
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Yi, Junkoo
;
Choi, Dong Kyu
;
Kim, Myoung Ok
;
Lee, Hyun-Shik
;
Cho, Dong-Hyung
;
Young Ryoo, Zae
Parkinson's disease (PD) is a progressive neurological disorder characterized by the degeneration of midbrain dopaminergic neurons and disabling motor impairments. Heat shock protein family A member 9 (HSPA9) play a crucial role in neuronal homeostasis by regulating the import of various mitochondrial proteins. HSPA9 is down-regulated in neurodegenerative diseases such as Alzheimer's disease and PD, and its loss leads to excessive mitochondrial fragmentation with oxidative stress, whic