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APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

Article
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
  • Lee, Se-In ; 
  • Jeong, Woojin ; 
  • Lim, Heejin ; 
  • Cho, Sukhee ; 
  • Lee, Hyein ; 
  • Jang, Yonghee ; 
  • Cho, Joonho ; 
  • Bae, Simsung ; 
  • Lin, Yuan-Ta ; 
  • Tsai, Li-Huei ; 
    • et al
  • 2021-09
  • Lee, Se-In. (2021-09). APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation. Stem Cell Reports, 16(9), 2128–2137. doi: 10.1016/j.stemcr.2021.07.017
  • Cell Press
  • View : 978
  • Download : 65

ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes

Article
ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
  • Lee, Hyein ; 
  • Cho, Sukhee ; 
  • Kim, Mi-Jin ; 
  • Park, Yeo Jin ; 
  • Cho, Eunji ; 
  • Jo, Yeon Suk ; 
  • Kim, Yong-Seok ; 
  • Lee, Jung Yi ; 
  • Thoudam, Themis ; 
  • Woo, Seung-Hwa ; 
    • et al
  • 2023-10
  • Lee, Hyein. (2023-10). ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes. Cell Reports, 42(10). doi: 10.1016/j.celrep.2023.113183
  • Cell Press
  • View : 549
  • Download : 120

Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4

Article
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
  • Lee, Se-In ; 
  • Yu, Jichang ; 
  • Lee, Hyein ; 
  • Kim, Buyun ; 
  • Jang, Min Jun ; 
  • Jo, Hyeonbin ; 
  • Kim, Na Yeon ; 
  • Pak, Malk Eun ; 
  • Kim, Jae Kwang ; 
  • Cho, Sukhee ; 
    • et al
  • 2025-08
  • Nature Communications, v.16, no.1
  • Nature Publishing Group
  • View : 248
  • Download : 157

Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons

Article
Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons
  • Lee, Se-In ; 
  • Lim, Heejin ; 
  • Kim, Na Yeon ; 
  • Yu, Jichang ; 
  • Cho, Joonho ; 
  • Lee, Hyein ; 
  • Moon, Dae Won ; 
  • Seo, Jinsoo
  • 2025-02
  • Lee, Se-In. (2025-02). Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons. iScience, 28(2). doi: 10.1016/j.isci.2025.111893
  • Cell Press
  • View : 273
  • Download : 168
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