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Bee venom attenuates Porphyromonas gingivalis and RANKL-induced bone resorption with osteoclastogenic differentiation

Title
Bee venom attenuates Porphyromonas gingivalis and RANKL-induced bone resorption with osteoclastogenic differentiation
Authors
Gu, HyeminAn, Hyun-JinKim, Jung-YeonKim, Woon-HaeGwon, Mi-GyeongKim, Hyun-JuHan, Sang MiPark, InSookPark, Sok CheonLeem, JaechanPark, Kwan-Kyu
DGIST Authors
Kim, Woon-Hae
Issue Date
2019-07
Citation
Food and Chemical Toxicology, 129, 344-353
Type
Article
Article Type
Article
Author Keywords
Bee venomInflammationOsteoclastogenesisPeriodontal diseases
Keywords
NF-KAPPA-BRECEPTOR ACTIVATORNUCLEAR-FACTORRESORBING ACTIVITYDC-STAMPPERIODONTITISLIGANDLIPOPOLYSACCHARIDEINFLAMMATIONARTHRITIS
ISSN
0278-6915
Abstract
Porphyromonas gingivalis (P. gingivalis) is one of the major periodontal pathogens leading to inflammation and alveolar bone resorption. Bone resorption is induced by osteoclasts, which are multinucleated giant cells. Osteoclastic bone resorption is mediated by enhanced receptor activator of nuclear factor-kappa B ligand (RANKL) signaling. Therefore, the down-regulation of RANKL downstream signals is regarded as an effective therapeutic target in the treatment of bone loss-associated disorders. The aim of this study was to evaluate whether purified bee venom (BV) could attenuate P. gingivalis-induced inflammatory periodontitis and RANKL-induced osteoclast differentiation. Inflammatory periodontitis induced by P. gingivalis increased alveolar bone resorption and increased expression of TNF-α and IL-1β, while BV treatment resulted in decreased bone loss and pro-inflammatory cytokines. Similarly, RANKL-induced multinucleated osteoclast differentiation and osteoclast-specific gene expression, such as nuclear factor of activated T cells 1 (NFATc1), cathepsin K, tartrate-resistant acid phosphatase (TRAP), and integrin αvβ3 were significantly suppressed by treatment with BV. We show that BV reduces P. gingivalis-induced inflammatory bone loss-related periodontitis in vivo and RANKL-induced osteoclast differentiation, activation, and function in vitro. These results suggest that BV exerts positive effects on inflammatory periodontitis associated osteoclastogenesis. © 2019 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/10116
DOI
10.1016/j.fct.2019.05.001
Publisher
Elsevier BV
Files:
There are no files associated with this item.
Collection:
Department of New BiologyETC1. Journal Articles


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