Cited 4 time in webofscience Cited 2 time in scopus

ALWPs Improve Cognitive Function and Regulate A beta Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease

Title
ALWPs Improve Cognitive Function and Regulate A beta Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease
Authors
Nam, YoungpyoJoo, BitnaLee, Ju-YoungHan, Kyung-MinRyu, Ka-YoungKoh, Young HoKim, JeongyeonKoo, Ja WookWe, Young-ManHoe, Hyang-Sook
Issue Date
2019-08
Citation
Frontiers in Molecular Neuroscience, 12
Type
Article
Article Type
Article
Author Keywords
A betatauAlzheimer&aposs diseasemyloid plaquelong-term memorydendritic spines
Keywords
TRADITIONAL CHINESE MEDICINEINDUCED MEMORY IMPAIRMENTDENDRITIC SPINE LOSSRAT MODELPROTEINNEURONSTANGLTPAPPNEUROINFLAMMATION
ISSN
1662-5099
Abstract
Recently, we reported that ALWPs, which we developed by combining Liuwei Dihuang pills (LWPs) with antler, regulate the LPS-induced neuroinflammatory response and rescue LPS-induced short- and long-term memory impairment in wild-type (WT) mice. In the present study, we examined the effects of ALWPs on Alzheimer’s disease (AD) pathology and cognitive function in WT mice as well as 5x FAD mice (a mouse model of AD). We found that administration of ALWPs significantly reduced amyloid plaque levels in 5x FAD mice and significantly decreased amyloid β (Aβ) levels in amyloid precursor protein (APP)-overexpressing H4 cells. In addition, ALWPs administration significantly suppressed tau hyperphosphorylation in 5x FAD mice. Oral administration of ALWPs significantly improved long-term memory in scopolamine (SCO)-injected WT mice and 5x FAD mice by altering dendritic spine density. Importantly, ALWPs promoted spinogenesis in primary hippocampal neurons and WT mice and modulated the dendritic spine number in an extracellular signal-regulated kinase (ERK)-dependent manner. Taken together, our results suggest that ALWPs are a candidate therapeutic drug for AD that can modulate amyloid plaque load, tau phosphorylation, and synaptic/cognitive function. © Copyright © 2019 Nam, Joo, Lee, Han, Ryu, Koh, Kim, Koo, We and Hoe.
URI
http://hdl.handle.net/20.500.11750/10639
DOI
10.3389/fnmol.2019.00192
Publisher
Frontiers Media S.A.
Files:
Collection:
ETC1. Journal Articles


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