상온과 상압에서 퍼옥소 코발트 복합체를 사용하여 나이트릴 관능기를 하이드록사믹 엑시드 관능기로 전환시키는 방법

Abstract

The method of the present invention for converting a nitrile functional group into a hydroxamic acid functional group can be easily performed at room temperature and under normal pressure by using a peroxocobalt complex. The final hydroxamic acid functional group produced through the intermediate Hydroximatocobalt (III) compound or the derivative comprising the same has been known to be able to inhibit the growth of cancer cells, so that the conversion method of the present invention can be applied to the preparation of a pro-drug for anticancer treatment.