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도파민 뉴런 유사 세포군집체 및 그 제조방법

Title
도파민 뉴런 유사 세포군집체 및 그 제조방법
Translated Title
Dopaminergic neuron-like cell cluster and method for preparing the same
Inventors
정권수이경민전원배
DGIST Inventors
이경민전원배
Country
FR
Application Date
2014-07-31
Application No.
EP14179316.6
Registration Date
2018-10-31
Registration No.
EP2845899
Assignee
(재)대구경북과학기술원(100/100)
URI
http://hdl.handle.net/20.500.11750/11309
Abstract
Disclosed are a dopaminergic neuron-like cell cluster exhibiting a far higher level of a dopaminergic neuron marker, compared to conventional 2D or 3D cultured cells, and a method for preparing the same. The cell cluster can be more effectively differentiated into dopaminergic neurons in the presence of a differentiation-inducing factor, so that it is suitable for use in studying neurodegenerative diseases such as Parkinson's disease. In addition, the cell cluster can express factors reinforcing intercellular interaction at an improved level, and is free of cellular toxicity and safe to the body, easy to culture with high productivity, superior in biocompatibility, and highly unlikely to undergo mutations. Also provided is a dish for culturing a 3D dopaminergic neuron-like cell cluster on a mass scale; which guarantees the 3D dopaminergic neuron-like cell cluster superior biocompatibility, freedom of cellular toxicity, minimal mutagenicity, and improvement in the expression of factors reinforcing intercellular interaction.
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Files:
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Collection:
Division of Biotechnology3. Patents


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