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In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles
- In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles
- Faruque, Md Hasan Al; Kim, Jung-Hee; Choi, Eun-Sook; Kim, Soonhyun; Kim, Eunjoo
- DGIST Authors
- Kim, Jung-Hee; Kim, Soonhyun; Kim, Eunjoo
- Issue Date
- Nanomedicine, 14(24), 3143-3158
- Article Type
- Author Keywords
- in vivo; iron oxide nanoparticles; Prussian blue; radioactive cesium
- Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for their Cs adsorption properties in vitro and in vivo. The distribution of the adsorbents was also evaluated in C57BL/6 mice. Results: PB-deposited MNPs provided an improved adsorbent capacity for Cs removal and reduced toxicity to blood cells compared with those of bulk PB. Conclusion: PB-deposited MNPs could be considered as an alternative of PB-based medicine to reduce the possible hazards caused by high dose of PB intake. © 2019 Future Medicine Ltd.
- Future Medicine Ltd.
- Related Researcher
Biomarker, liquid biopsy, molecular diagnosis, nanobiosensor, drug delivery, exosome
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