Cited 4 time in webofscience Cited 3 time in scopus

Core transcriptional regulatory circuits in prion diseases

Title
Core transcriptional regulatory circuits in prion diseases
Authors
Kim, Taek-KyunLee, InyoulCho, Ji-HoonCanine, BrendaKeller, AndrewPrice, Nathan D.Hwang, DaeheeCarlson, GeorgeHood, Leroy
DGIST Authors
Kim, Taek-Kyun; Lee, Inyoul; Cho, Ji-Hoon; Canine, Brenda; Keller, Andrew; Price, Nathan D.; Hwang, Daehee; Carlson, George; Hood, Leroy
Issue Date
2020-01
Citation
Molecular Brain, 13(1), 10
Type
Article
Article Type
Article
Author Keywords
Murine PrP-prion diseaseGene expressionTranscriptional regulatory circuitsFeed-forward loopsBrain cell type
Keywords
ALZHEIMERS-DISEASENETWORK MOTIFSEXPRESSIONPATHWAYBRAINACTIVATIONAPOPTOSISBIOLOGYCELLSDEATH
ISSN
1756-6606
Abstract
Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early and late perturbations in prion disease. We first identified cellular processes perturbed early and late using time-course gene expression data from three prion-infected mouse strains. We then built a transcriptional regulatory network (TRN) describing regulation of early and late processes. We found over-represented feed-forward loops (FFLs) comprising transcription factor (TF) pairs and target genes in the TRN. Using gene expression data of brain cell types, we further selected active FFLs where TF pairs and target genes were expressed in the same cell type and showed correlated temporal expression changes in the brain. We finally determined core transcriptional regulatory circuits by combining these active FFLs. These circuits provide insights into transcriptional programs for early and late pathophysiological processes in prion disease. © 2020 The Author(s).
URI
http://hdl.handle.net/20.500.11750/11657
DOI
10.1186/s13041-020-0551-3
Publisher
BioMed Central
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