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dc.contributor.author Joo, Bitna -
dc.contributor.author Koo, Ja Wook -
dc.contributor.author Lee, Sukwon -
dc.date.accessioned 2020-04-13T05:34:18Z -
dc.date.available 2020-04-13T05:34:18Z -
dc.date.created 2020-04-13 -
dc.date.issued 2020-02 -
dc.identifier.citation Molecular Brain, v.13, no.1, pp.16 -
dc.identifier.issn 1756-6606 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/11660 -
dc.description.abstract The return of fear following extinction therapy is an important issue associated with the treatment of many fear-related disorders. Fear renewal is a suitable model, with which context-dependent modulation of the fear response can be examined. In this model, any context outside of an extinction context (e.g., novel or familiar contexts) could evoke relapse of the fear response. However, brain regions associated with context-dependent modulation are not fully understood. The posterior parietal cortex (PPC) is considered a center for integrating multisensory information and making decisions. To study its role in the contextual modulation of fear relapse, we reversibly inactivated the PPC in mice before they were exposed to various contexts after extinction training. When muscimol was infused into the PPC, fear renewal was impaired in a novel context, but not in a familiar context. Fear relapses were blocked during optogenetic inhibition of the PPC, only when animals were placed in a novel context. We propose that the neural activity of the PPC is necessary for the relapse of a precise response to an extinguished conditioned stimulus in a novel context. © 2020 The Author(s). -
dc.language English -
dc.publisher BioMed Central -
dc.title Posterior parietal cortex mediates fear renewal in a novel context -
dc.type Article -
dc.identifier.doi 10.1186/s13041-020-0556-y -
dc.identifier.wosid 000521221100001 -
dc.identifier.scopusid 2-s2.0-85079054684 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Molecular Brain -
dc.contributor.nonIdAuthor Joo, Bitna -
dc.contributor.nonIdAuthor Koo, Ja Wook -
dc.contributor.nonIdAuthor Lee, Sukwon -
dc.identifier.citationVolume 13 -
dc.identifier.citationNumber 1 -
dc.identifier.citationStartPage 16 -
dc.identifier.citationTitle Molecular Brain -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor Posterior parietal cortex -
dc.subject.keywordAuthor Learning and memory -
dc.subject.keywordAuthor Fear renewal -
dc.subject.keywordAuthor Optogenetics -
dc.subject.keywordAuthor Novel context -
dc.subject.keywordPlus HIPPOCAMPAL INACTIVATION -
dc.subject.keywordPlus PREFRONTAL CORTEX -
dc.subject.keywordPlus CONDITIONAL FEAR -
dc.subject.keywordPlus EXTINCTION -
dc.subject.keywordPlus MEMORY -
dc.subject.keywordPlus RETRIEVAL -
dc.subject.keywordPlus AMYGDALA -
dc.subject.keywordPlus INFORMATION -
dc.subject.keywordPlus LESIONS -
dc.contributor.affiliatedAuthor Joo, Bitna -
dc.contributor.affiliatedAuthor Koo, Ja Wook -
dc.contributor.affiliatedAuthor Lee, Sukwon -
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