Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li J.J. | ko |
dc.contributor.author | Ryou C.S. | ko |
dc.contributor.author | Kim, Dae-Hwan | ko |
dc.date.accessioned | 2020-07-06T07:10:56Z | - |
dc.date.available | 2020-07-06T07:10:56Z | - |
dc.date.created | 2020-06-16 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Molekulyarnaya Biologiya, v.54, no.3, pp.469 - 473 | - |
dc.identifier.issn | 0026-8984 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12038 | - |
dc.description.abstract | Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrP^(Sc) in prion-infected cells. Herein, we confirm the elimination of PrP^(Sc) in chronic wasting disease (CWD) prion-infected neurons by SGI-1027, and pinpoint the binding region of human prion protein to SGI-1027. SGI-1027 is broadly functional against various prion disease types, including human prions. Previously, the inhibitory effects of SGI-1027 on DNMT function is well tested in various cell culture models. While neither treatment with a DNMTs enhancer S-adenosyl-L-methionine (SAM), nor with their inhibitor, 5-azacytidine, prevented PrP^(Sc) propagation, SGI-1027 did. Our study suggest that the anti-prion effects of SGI-1027 are a result of its direct interaction with PrP^(C), which effectively interferes with the pathogenic conformational change of PrP^(C) to PrP^(Sc). We conclude that SGI-1027 driven suppression of pathogenic PrP^(Sc) is independent of DNMT. | - |
dc.language | Russian | - |
dc.publisher | Russian Academy of Sciences | - |
dc.title | Effects of SGI-1027 on Formation and Elimination of PrP^(Sc) in Prion-Infected Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.31857/S0026898420030118 | - |
dc.identifier.scopusid | 2-s2.0-85085910111 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Li J.J. | - |
dc.contributor.nonIdAuthor | Ryou C.S. | - |
dc.identifier.citationVolume | 54 | - |
dc.identifier.citationNumber | 3 | - |
dc.identifier.citationStartPage | 469 | - |
dc.identifier.citationEndPage | 473 | - |
dc.identifier.citationTitle | Molekulyarnaya Biologiya | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | DNA methyl transferase | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | prion | - |
dc.subject.keywordAuthor | PrP^(Sc) | - |
dc.subject.keywordAuthor | SGI-1027 | - |
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