Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Li, J. J. | ko |
dc.contributor.author | Ryou, C. S. | ko |
dc.contributor.author | Kim, Dae-Hwan | ko |
dc.date.accessioned | 2020-08-19T10:38:39Z | - |
dc.date.available | 2020-08-19T10:38:39Z | - |
dc.date.created | 2020-07-02 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Molecular Biology, v.54, no.3, pp.412 - 415 | - |
dc.identifier.issn | 0026-8933 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12246 | - |
dc.description.abstract | Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrPSc in prion-infected cells. Herein, we confirm the elimination of PrPSc in chronic wasting disease (CWD) prion-infected neurons by SGI-1027, and pinpoint the binding region of human prion protein to SGI-1027. SGI-1027 is broadly functional against various prion disease types, including human prions. Previously, the inhibitory effects of SGI-1027 on DNMT function is well tested in various cell culture models. While neither treatment with a DNMTs enhancer S-adenosyl-L-methionine (SAM), nor with their inhibitor, 5-azacytidine, prevented PrPSc propagation, SGI-1027 did. Our study suggest that the anti-prion effects of SGI-1027 are a result of its direct interaction with PrPC, which effectively interferes with the pathogenic conformational change of PrPC to PrPSc. We conclude that SGI-1027 driven suppression of pathogenic PrPSc is independent of DNMT. © 2020, Pleiades Publishing, Inc. | - |
dc.language | English | - |
dc.publisher | Maik Nauka/Interperiodica Publishing | - |
dc.title | Effects of SGI-1027 on Formation and Elimination of PrP(Sc)in Prion-Infected Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1134/S0026893320030115 | - |
dc.identifier.wosid | 000540780400012 | - |
dc.identifier.scopusid | 2-s2.0-85086600028 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Li, J. J. | - |
dc.contributor.nonIdAuthor | Ryou, C. S. | - |
dc.identifier.citationVolume | 54 | - |
dc.identifier.citationNumber | 3 | - |
dc.identifier.citationStartPage | 412 | - |
dc.identifier.citationEndPage | 415 | - |
dc.identifier.citationTitle | Molecular Biology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | prion | - |
dc.subject.keywordAuthor | PrPSc | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | DNA methyl transferase | - |
dc.subject.keywordAuthor | SGI-1027 | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | INHIBITORS | - |
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