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Breakdown of chiral recognition of amino acids in reduced dimensions

Title
Breakdown of chiral recognition of amino acids in reduced dimensions
Authors
Jeong, Yong ChanKim, Hyo WonKu, JiYeonSeo, Jungpil
DGIST Authors
Jeong, Yong Chan; Kim, Hyo Won; Ku, JiYeon; Seo, Jungpil
Issue Date
2020-09
Citation
Scientific Reports, 10(1), 16166
Type
Article
Article Type
Article
Keywords
SCANNING-TUNNELING-MICROSCOPYTOTAL-ENERGY CALCULATIONSR-ALANINES-ALANINECYSTEINEADSORPTIONAMPLIFICATIONASSEMBLIESMOLECULES
ISSN
2045-2322
Abstract
The homochirality of amino acids in living organisms is one of the great mysteries in the phenomena of life. To understand the chiral recognition of amino acids, we have used scanning tunnelling microscopy to investigate the self-assembly of molecules of the amino acid tryptophan (Trp) on Au(111). Earlier experiments showed only homochiral configurations in the self-assembly of amino acids, despite using a mixture of the two opposite enantiomers. In our study, we demonstrate that heterochiral configurations can be favored energetically when l- and d-Trp molecules are mixed to form self-assembly on the Au surface. Using density functional theory calculations, we show that the indole side chain strongly interacts with the Au surface, which reduces the system effectively to two-dimension, with chiral recognition disabled. Our study provides important insight into the recognition of the chirality of amino acid molecules in life. © 2020, The Author(s).
URI
http://hdl.handle.net/20.500.11750/12612
DOI
10.1038/s41598-020-73300-z
Publisher
Nature Publishing Group
Related Researcher
  • Author Seo, Jungpil Nanospm Lab(Advanced Materials Research Group)
  • Research Interests Topological Matters; High Tc Superconductors; Low dimensional Quantum Matters
Files:
Collection:
Department of Emerging Materials ScienceNanospm Lab(Advanced Materials Research Group)1. Journal Articles


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