Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Leibold, Nicole K. | - |
dc.contributor.author | van den Hove, Daniel L. A. | - |
dc.contributor.author | Weidner, Magdalena T. | - |
dc.contributor.author | Buchanan, Gordon F. | - |
dc.contributor.author | Steinbusch, Hendrik Wilhelm Maria | - |
dc.contributor.author | Lesch, Klaus-Peter | - |
dc.contributor.author | Schruers, Koen R. J. | - |
dc.date.accessioned | 2021-01-22T07:37:13Z | - |
dc.date.available | 2021-01-22T07:37:13Z | - |
dc.date.created | 2020-11-13 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Journal of Psychopharmacology, v.34, no.12, pp.1408 - 1417 | - |
dc.identifier.issn | 0269-8811 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12806 | - |
dc.description.abstract | Background: Inhaling 35% carbon dioxide induces an emotional and symptomatic state in humans closely resembling naturally occurring panic attacks, the core symptom of panic disorder. Previous research has suggested a role of the serotonin system in the individual sensitivity to carbon dioxide. In line with this, we previously showed that a variant in the SLC6A4 gene, encoding the serotonin transporter, moderates the fear response to carbon dioxide in humans. To study the etiological basis of carbon dioxide-reactivity and panic attacks in more detail, we recently established a translational mouse model. Aim: The purpose of this study was to investigate whether decreased expression of the serotonin transporter affects the sensitivity to carbon dioxide. Methods: Based on our previous work, wildtype and serotonin transporter deficient (+/–, –/–) mice were monitored while being exposed to carbon dioxide-enriched air. In wildtype and serotonin transporter +/– mice, also cardio-respiration was assessed. Results: For most behavioral measures under air exposure, wildtype and serotonin transporter +/– mice did not differ, while serotonin transporter –/– mice showed more fear-related behavior. Carbon dioxide exposure evoked a marked increase in fear-related behaviors, independent of genotype, with the exception of time serotonin transporter –/– mice spent in the center zone of the modified open field test and freezing in the two-chamber test. On the physiological level, when inhaling carbon dioxide, the respiratory system was strongly activated and heart rate decreased independent of genotype. Conclusion: Carbon dioxide is a robust fear-inducing stimulus. It evokes inhibitory behavioral responses such as decreased exploration and is associated with a clear respiratory profile independent of serotonin transporter genotype. © The Author(s) 2020. | - |
dc.language | English | - |
dc.publisher | SAGE Publications | - |
dc.title | Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0269881120959611 | - |
dc.identifier.wosid | 000595100600008 | - |
dc.identifier.scopusid | 2-s2.0-85093952099 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Journal of Psychopharmacology | - |
dc.contributor.nonIdAuthor | Leibold, Nicole K. | - |
dc.contributor.nonIdAuthor | van den Hove, Daniel L. A. | - |
dc.contributor.nonIdAuthor | Weidner, Magdalena T. | - |
dc.contributor.nonIdAuthor | Buchanan, Gordon F. | - |
dc.contributor.nonIdAuthor | Steinbusch, Hendrik Wilhelm Maria | - |
dc.contributor.nonIdAuthor | Lesch, Klaus-Peter | - |
dc.contributor.nonIdAuthor | Schruers, Koen R. J. | - |
dc.identifier.citationVolume | 34 | - |
dc.identifier.citationNumber | 12 | - |
dc.identifier.citationStartPage | 1408 | - |
dc.identifier.citationEndPage | 1417 | - |
dc.identifier.citationTitle | Journal of Psychopharmacology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | carbon dioxide | - |
dc.subject.keywordAuthor | Panic attacks | - |
dc.subject.keywordAuthor | panic disorder | - |
dc.subject.keywordAuthor | serotonin transporter | - |
dc.contributor.affiliatedAuthor | Leibold, Nicole K. | - |
dc.contributor.affiliatedAuthor | van den Hove, Daniel L. A. | - |
dc.contributor.affiliatedAuthor | Weidner, Magdalena T. | - |
dc.contributor.affiliatedAuthor | Buchanan, Gordon F. | - |
dc.contributor.affiliatedAuthor | Steinbusch, Hendrik Wilhelm Maria | - |
dc.contributor.affiliatedAuthor | Lesch, Klaus-Peter | - |
dc.contributor.affiliatedAuthor | Schruers, Koen R. J. | - |
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