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dc.contributor.author Leibold, Nicole K. -
dc.contributor.author van den Hove, Daniel L. A. -
dc.contributor.author Weidner, Magdalena T. -
dc.contributor.author Buchanan, Gordon F. -
dc.contributor.author Steinbusch, Hendrik Wilhelm Maria -
dc.contributor.author Lesch, Klaus-Peter -
dc.contributor.author Schruers, Koen R. J. -
dc.date.accessioned 2021-01-22T07:37:13Z -
dc.date.available 2021-01-22T07:37:13Z -
dc.date.created 2020-11-13 -
dc.date.created 2020-11-13 -
dc.date.issued 2020-12 -
dc.identifier.citation Journal of Psychopharmacology, v.34, no.12, pp.1408 - 1417 -
dc.identifier.issn 0269-8811 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12806 -
dc.description.abstract Background: Inhaling 35% carbon dioxide induces an emotional and symptomatic state in humans closely resembling naturally occurring panic attacks, the core symptom of panic disorder. Previous research has suggested a role of the serotonin system in the individual sensitivity to carbon dioxide. In line with this, we previously showed that a variant in the SLC6A4 gene, encoding the serotonin transporter, moderates the fear response to carbon dioxide in humans. To study the etiological basis of carbon dioxide-reactivity and panic attacks in more detail, we recently established a translational mouse model. Aim: The purpose of this study was to investigate whether decreased expression of the serotonin transporter affects the sensitivity to carbon dioxide. Methods: Based on our previous work, wildtype and serotonin transporter deficient (+/–, –/–) mice were monitored while being exposed to carbon dioxide-enriched air. In wildtype and serotonin transporter +/– mice, also cardio-respiration was assessed. Results: For most behavioral measures under air exposure, wildtype and serotonin transporter +/– mice did not differ, while serotonin transporter –/– mice showed more fear-related behavior. Carbon dioxide exposure evoked a marked increase in fear-related behaviors, independent of genotype, with the exception of time serotonin transporter –/– mice spent in the center zone of the modified open field test and freezing in the two-chamber test. On the physiological level, when inhaling carbon dioxide, the respiratory system was strongly activated and heart rate decreased independent of genotype. Conclusion: Carbon dioxide is a robust fear-inducing stimulus. It evokes inhibitory behavioral responses such as decreased exploration and is associated with a clear respiratory profile independent of serotonin transporter genotype. © The Author(s) 2020. -
dc.language English -
dc.publisher SAGE Publications -
dc.title Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice -
dc.type Article -
dc.identifier.doi 10.1177/0269881120959611 -
dc.identifier.wosid 000595100600008 -
dc.identifier.scopusid 2-s2.0-85093952099 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Journal of Psychopharmacology -
dc.contributor.localauthor Leibold, Nicole K. -
dc.contributor.localauthor van den Hove, Daniel L. A. -
dc.contributor.localauthor Weidner, Magdalena T. -
dc.contributor.localauthor Buchanan, Gordon F. -
dc.contributor.localauthor Steinbusch, Hendrik Wilhelm Maria -
dc.contributor.localauthor Lesch, Klaus-Peter -
dc.contributor.localauthor Schruers, Koen R. J. -
dc.contributor.nonIdAuthor Leibold, Nicole K. -
dc.contributor.nonIdAuthor van den Hove, Daniel L. A. -
dc.contributor.nonIdAuthor Weidner, Magdalena T. -
dc.contributor.nonIdAuthor Buchanan, Gordon F. -
dc.contributor.nonIdAuthor Steinbusch, Hendrik Wilhelm Maria -
dc.contributor.nonIdAuthor Lesch, Klaus-Peter -
dc.contributor.nonIdAuthor Schruers, Koen R. J. -
dc.identifier.citationVolume 34 -
dc.identifier.citationNumber 12 -
dc.identifier.citationStartPage 1408 -
dc.identifier.citationEndPage 1417 -
dc.identifier.citationTitle Journal of Psychopharmacology -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor carbon dioxide -
dc.subject.keywordAuthor Panic attacks -
dc.subject.keywordAuthor panic disorder -
dc.subject.keywordAuthor serotonin transporter -
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