Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kwon, Nam | - |
dc.contributor.author | Suh, Jong-Min | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.contributor.author | Hirao, Hajime | - |
dc.contributor.author | Cho, Jaeheung | - |
dc.date.accessioned | 2021-01-22T07:56:46Z | - |
dc.date.available | 2021-01-22T07:56:46Z | - |
dc.date.created | 2020-09-16 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12843 | - |
dc.description.abstract | A hydroxamate transfer reaction between metal complexes has been investigated by a combination of experimental and theoretical studies. A hydroxamate-bound cobalt(ii) complex bearing a tetradentate macrocyclic ligand, [Co-II(TBDAP)(CH3C(-NHO)O)](+)(1), is prepared by the reduction of a hydroximatocobalt(iii) complex with a biological reductant. Alternatively,1is accessibleviaa synthetic route for the reaction between the cobalt(ii) complex and acetohydroxamic acid in the presence of a base.1was isolated and characterized by various physicochemical methods, including UV-vis, IR, ESI-MS, and X-ray crystallography. The hydroxamate transfer reactivity of1was examined with a zinc complex, which was followed by UV-vis and ESI-MS. Kinetic and activation parameter data suggest that the hydroxamate transfer reaction occursviaa bimolecular mechanism, which is also supported by DFT calculations. Moreover,1is able to inhibit the activity against a zinc enzyme,i.e., matrix metalloproteinase-9. Our overall investigations of the hydroxamate transfer using the synthetic model system provide considerable insight into the final step involved in the inhibition of zinc-containing enzymes. | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Mechanistic insight into hydroxamate transfer reaction mimicking the inhibition of zinc-containing enzymes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d0sc02676j | - |
dc.identifier.scopusid | 2-s2.0-85090049525 | - |
dc.identifier.bibliographicCitation | Chemical Science, v.11, no.33, pp.9017 - 9021 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE INHIBITORS | - |
dc.subject.keywordPlus | COBALT COMPLEXES | - |
dc.subject.keywordPlus | CARBONIC-ANHYDRASE | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | ACIDS | - |
dc.citation.endPage | 9021 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 9017 | - |
dc.citation.title | Chemical Science | - |
dc.citation.volume | 11 | - |