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Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

Title
Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice
Author(s)
Park, GaeunRyu, ChanghyeonKim, SoobinJeong, Se JinKoo, Ja WookLee, Yong-SeokKim, Sang Jeong
DGIST Authors
Park, GaeunRyu, ChanghyeonKim, SoobinJeong, Se JinKoo, Ja WookLee, Yong-SeokKim, Sang Jeong
Issued Date
2021-05
Type
Article
Author Keywords
infralimbic cortexnucleus accumbensresocializationsocial deficitsocial familiaritysocial isolationsocial recognition
Keywords
animal experimentarticlecontrolled studyexcitabilityinfralimbic cortexmalemousenerve cellnonhumannucleus accumbenssocial isolationweaning
ISSN
2211-1247
Abstract
Although medial prefrontal cortex (mPFC) is known to play important roles in social behaviors, how early social experiences affect the mPFC and its subcortical circuit remains unclear. We report that mice singly housed (SH) for 8 weeks after weaning show a social recognition deficit, even after 4 weeks of resocialization. In SH mice, prefrontal infralimbic (IL) neurons projecting to the shell region of nucleus accumbens (NAcSh) show decreased excitability compared with group-housed (GH) mice. NAcSh-projecting IL neurons are activated when GH mice encounter a familiar conspecific, which is not observed in SH mice. Chemogenetic inhibition of NAcSh-projecting IL neurons in normal mice impairs social recognition without affecting social preference, whereas activation of these neurons reverses social recognition deficit in SH mice. Our findings demonstrate that early social experience critically affects mPFC IL-NAcSh projection, the activation of which is required for social recognition by encoding information for social familiarity. © 2021 The Author(s)
URI
http://hdl.handle.net/20.500.11750/15410
DOI
10.1016/j.celrep.2021.109104
Publisher
Cell Press
Files in This Item:
Appears in Collections:
Department of Brain Sciences ETC 1. Journal Articles

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