Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Yum, Min Kyu | - |
dc.contributor.author | Han, Seungmin | - |
dc.contributor.author | Fink, Juergen | - |
dc.contributor.author | Wu, Szu-Hsien Sam | - |
dc.contributor.author | Dabrowska, Catherine | - |
dc.contributor.author | Trendafilova, Teodora | - |
dc.contributor.author | Mustata, Roxana | - |
dc.contributor.author | Chatzeli, Lemonia | - |
dc.contributor.author | Azzarelli, Roberta | - |
dc.contributor.author | Pshenichnaya, Irina | - |
dc.contributor.author | Lee, Eun Min | - |
dc.contributor.author | England, Frances | - |
dc.contributor.author | Kim, Jong Kyoung | - |
dc.contributor.author | Stange, Daniel E. | - |
dc.contributor.author | Philpott, Anna | - |
dc.contributor.author | Lee, Joo-Hyeon | - |
dc.contributor.author | Koo, Bon-Kyoung | - |
dc.contributor.author | Simons, Benjamin D. | - |
dc.date.accessioned | 2021-10-07T03:00:15Z | - |
dc.date.available | 2021-10-07T03:00:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15421 | - |
dc.description.abstract | Interactions between tumour cells and the surrounding microenvironment contribute to tumour progression, metastasis and recurrence(1-3). Although mosaic analyses in Drosophila have advanced our understanding of such interactions(4,5), it has been difficult to engineer parallel approaches in vertebrates. Here we present an oncogene-associated, multicolour reporter mouse model-the Red2Onco system-that allows differential tracing of mutant and wild-type cells in the same tissue. By applying this system to the small intestine, we show that oncogene-expressing mutant crypts alter the cellular organization of neighbouring wild-type crypts, thereby driving accelerated clonal drift. Crypts that express oncogenic KRAS or PI3K secrete BMP ligands that suppress local stem cell activity, while changes in PDGFR(lo)CD81(+) stromal cells induced by crypts with oncogenic PI3K alter the WNT signalling environment. Together, these results show how oncogene-driven paracrine remodelling creates a niche environment that is detrimental to the maintenance of wild-type tissue, promoting field transformation dominated by oncogenic clones. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Tracing oncogene-driven remodelling of the intestinal stem cell niche | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41586-021-03605-0 | - |
dc.identifier.wosid | 000657239300006 | - |
dc.identifier.scopusid | 2-s2.0-85107314339 | - |
dc.identifier.bibliographicCitation | Nature, v.594, no.7863, pp.442 - + | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | MICROENVIRONMENTAL REGULATION | - |
dc.subject.keywordPlus | FIELD CANCERIZATION | - |
dc.subject.keywordPlus | TUMOR PROGRESSION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | COMPETITION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EPITHELIUM | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.citation.endPage | + | - |
dc.citation.number | 7863 | - |
dc.citation.startPage | 442 | - |
dc.citation.title | Nature | - |
dc.citation.volume | 594 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.type.docType | Article | - |
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