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Proteomic Interrogation in Cancer Biomarker

Title
Proteomic Interrogation in Cancer Biomarker
Authors
Kang, Un-Beom
DGIST Authors
Kang, Un-Beom
Issue Date
2021
Citation
Advances in Experimental Medicine and Biology, 1187, 305-322
Type
Article
Author Keywords
CancerBiomarkerProteomicsProteogenomicsClinical application
Keywords
MASS-SPECTROMETRYPLASMA PROTEOMEPOSTTRANSLATIONAL MODIFICATIONSQUANTITATIVE-ANALYSISSUPER-SILACIDENTIFICATIONPROTEINSEXPRESSIONVALIDATIONTISSUE
ISSN
0065-2598
Abstract
Biomarkers factor into the diagnosis and treatment of almost every patient with cancer. The innovation in proteomics follows improvement of mass spectrometry techniques and data processing strategy. Recently, proteomics and typical biological studies have been the answer for clinical applications. The clinical proteomics techniques are now actively adapted to protein identification in large patient cohort, biomarker development for more sensitive and specific screening based on quantitative data. And, it is important for clinical, translational researchers to be acutely aware of the issues surrounding appropriate biomarker development, in order to facilitate entry of clinically useful biomarkers into the clinic. Here, we discuss in detail include the case research for clinical proteomics. Furthermore, we give an overview on the current developments and novel findings in proteomics-based cancer biomarker research. © Springer Nature Singapore Pte Ltd. 2021.
URI
http://hdl.handle.net/20.500.11750/15462
DOI
10.1007/978-981-32-9620-6_15
Publisher
Kluwer Academic/Plenum Publishers
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