Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Jinhee | - |
dc.contributor.author | Jang, Soyoung | - |
dc.contributor.author | Choi, Minjee | - |
dc.contributor.author | Kang, Mincheol | - |
dc.contributor.author | Lim, Su-Geun | - |
dc.contributor.author | Kim, SI-Yong | - |
dc.contributor.author | Jang, Soyeon | - |
dc.contributor.author | Ko, Jiwon | - |
dc.contributor.author | Kim, Eungyung | - |
dc.contributor.author | Yi, Junkoo | - |
dc.contributor.author | Choo, Yeonsik | - |
dc.contributor.author | Kim, Myoung Ok | - |
dc.contributor.author | Ryoo, Zae Young | - |
dc.date.accessioned | 2021-10-15T06:00:09Z | - |
dc.date.available | 2021-10-15T06:00:09Z | - |
dc.date.created | 2021-08-19 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Scientific Reports, v.11, no.1, pp.16348 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15505 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms. © 2021, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-021-94855-5 | - |
dc.identifier.wosid | 000684343800082 | - |
dc.identifier.scopusid | 2-s2.0-85112305210 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Scientific Reports | - |
dc.contributor.nonIdAuthor | Lee, Jinhee | - |
dc.contributor.nonIdAuthor | Jang, Soyoung | - |
dc.contributor.nonIdAuthor | Choi, Minjee | - |
dc.contributor.nonIdAuthor | Kang, Mincheol | - |
dc.contributor.nonIdAuthor | Lim, Su-Geun | - |
dc.contributor.nonIdAuthor | Kim, SI-Yong | - |
dc.contributor.nonIdAuthor | Jang, Soyeon | - |
dc.contributor.nonIdAuthor | Ko, Jiwon | - |
dc.contributor.nonIdAuthor | Kim, Eungyung | - |
dc.contributor.nonIdAuthor | Yi, Junkoo | - |
dc.contributor.nonIdAuthor | Choo, Yeonsik | - |
dc.contributor.nonIdAuthor | Kim, Myoung Ok | - |
dc.contributor.nonIdAuthor | Ryoo, Zae Young | - |
dc.identifier.citationVolume | 11 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationStartPage | 16348 | - |
dc.identifier.citationTitle | Scientific Reports | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | I INTERFERONAUTOANTIBODIESERYTHEMATOSUSMECHANISMSINDUCTIONPRISTANEDISEASEMODELSCELLS | - |
dc.contributor.affiliatedAuthor | Lee, Jinhee | - |
dc.contributor.affiliatedAuthor | Jang, Soyoung | - |
dc.contributor.affiliatedAuthor | Choi, Minjee | - |
dc.contributor.affiliatedAuthor | Kang, Mincheol | - |
dc.contributor.affiliatedAuthor | Lim, Su-Geun | - |
dc.contributor.affiliatedAuthor | Kim, SI-Yong | - |
dc.contributor.affiliatedAuthor | Jang, Soyeon | - |
dc.contributor.affiliatedAuthor | Ko, Jiwon | - |
dc.contributor.affiliatedAuthor | Kim, Eungyung | - |
dc.contributor.affiliatedAuthor | Yi, Junkoo | - |
dc.contributor.affiliatedAuthor | Choo, Yeonsik | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Ok | - |
dc.contributor.affiliatedAuthor | Ryoo, Zae Young | - |