Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Chaturvedi, Richa | - |
dc.contributor.author | Kang, Yumin | - |
dc.contributor.author | Eom, Yunji | - |
dc.contributor.author | Torati, Sri Ramulu | - |
dc.contributor.author | Kim, CheolGi | - |
dc.date.accessioned | 2021-11-05T02:30:08Z | - |
dc.date.available | 2021-11-05T02:30:08Z | - |
dc.date.created | 2021-10-28 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | Biology, v.10, no.10 | - |
dc.identifier.issn | 2079-7737 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15753 | - |
dc.description.abstract | The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG–biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocy-tosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG–biotin to the MTB-through-NHS crosslinker to form a MTB/PEG– biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG– biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG–biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell’s surface, so as to make it a strong and reliable delivery agent. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.title | Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/biology10100993 | - |
dc.identifier.wosid | 000800164500001 | - |
dc.identifier.scopusid | 2-s2.0-85117241954 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Biology | - |
dc.contributor.nonIdAuthor | Chaturvedi, Richa | - |
dc.contributor.nonIdAuthor | Kang, Yumin | - |
dc.contributor.nonIdAuthor | Eom, Yunji | - |
dc.contributor.nonIdAuthor | Torati, Sri Ramulu | - |
dc.identifier.citationVolume | 10 | - |
dc.identifier.citationNumber | 10 | - |
dc.identifier.citationTitle | Biology | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | magnetotactic bacteria | - |
dc.subject.keywordAuthor | biotin | - |
dc.subject.keywordAuthor | polyethylene glycol | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | stealth property | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEM | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ACTUATORS | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.contributor.affiliatedAuthor | Chaturvedi, Richa | - |
dc.contributor.affiliatedAuthor | Kang, Yumin | - |
dc.contributor.affiliatedAuthor | Eom, Yunji | - |
dc.contributor.affiliatedAuthor | Torati, Sri Ramulu | - |
dc.contributor.affiliatedAuthor | Kim, CheolGi | - |