Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jeon, Yu.-Mi. | - |
dc.contributor.author | Kwon, Younghwi | - |
dc.contributor.author | Lee, Shinrye. | - |
dc.contributor.author | Kim, Seyeon | - |
dc.contributor.author | Jo, Myungjin. | - |
dc.contributor.author | Lee, Seongsoo. | - |
dc.contributor.author | Kim, Sang Ryong. | - |
dc.contributor.author | Kim, Kiyoung. | - |
dc.contributor.author | Kim, Hyung Jun | - |
dc.date.accessioned | 2022-01-14T08:00:02Z | - |
dc.date.available | 2022-01-14T08:00:02Z | - |
dc.date.created | 2022-01-07 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Antioxidants, v.11, no.1 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16093 | - |
dc.description.abstract | TAR DNA-binding protein 43 (TDP-43) is a member of an evolutionarily conserved family of heterogeneous nuclear ribonucleoproteins that modulate multiple steps in RNA metabolic processes. Cytoplasmic aggregation of TDP-43 in affected neurons is a pathological hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and limbic predominant age-related TDP-43 encephalopathy (LATE). Mislocalized and accumulated TDP-43 in the cytoplasm induces mitochondrial dysfunction and reactive oxidative species (ROS) production. Here, we show that TDP-43-and rotenone-in-duced neurotoxicity in the human neuronal cell line SH-SY5Y were attenuated by hydroxocobala-min (Hb, vitamin B12 analog) treatment. Although Hb did not affect the cytoplasmic accumulation of TDP-43, Hb attenuated TDP-43-induced toxicity by reducing oxidative stress and mitochondrial dysfunction. Moreover, a shortened lifespan and motility defects in TDP-43-expressing Drosophila were significantly mitigated by dietary treatment with hydroxocobalamin. Taken together, these findings suggest that oral intake of hydroxocobalamin may be a potential therapeutic intervention for TDP-43-associated proteinopathies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.title | Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/antiox11010082 | - |
dc.identifier.wosid | 000757575200001 | - |
dc.identifier.scopusid | 2-s2.0-85121768679 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Antioxidants | - |
dc.contributor.nonIdAuthor | Jeon, Yu.-Mi. | - |
dc.contributor.nonIdAuthor | Kwon, Younghwi | - |
dc.contributor.nonIdAuthor | Lee, Shinrye. | - |
dc.contributor.nonIdAuthor | Kim, Seyeon | - |
dc.contributor.nonIdAuthor | Jo, Myungjin. | - |
dc.contributor.nonIdAuthor | Lee, Seongsoo. | - |
dc.contributor.nonIdAuthor | Kim, Sang Ryong. | - |
dc.contributor.nonIdAuthor | Kim, Kiyoung. | - |
dc.contributor.nonIdAuthor | Kim, Hyung Jun | - |
dc.identifier.citationVolume | 11 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationTitle | Antioxidants | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | TAR DNA-binding protein 43 | - |
dc.subject.keywordAuthor | amyotrophic lateral sclerosis | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | mitochondrial dysfunction | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | TARDBP MUTATIONS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.contributor.affiliatedAuthor | Jeon, Yu.-Mi. | - |
dc.contributor.affiliatedAuthor | Kwon, Younghwi | - |
dc.contributor.affiliatedAuthor | Lee, Shinrye. | - |
dc.contributor.affiliatedAuthor | Kim, Seyeon | - |
dc.contributor.affiliatedAuthor | Jo, Myungjin. | - |
dc.contributor.affiliatedAuthor | Lee, Seongsoo. | - |
dc.contributor.affiliatedAuthor | Kim, Sang Ryong. | - |
dc.contributor.affiliatedAuthor | Kim, Kiyoung. | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jun | - |