RAD51 wrestles with SUMO
- Title
- RAD51 wrestles with SUMO
- Author(s)
- Kee, Younghoon ; Lee, Jung-Hee ; You, Ho Jin
- Issued Date
- 2022-12
- Citation
- Molecular and Cellular Oncology, v.9, no.1
- Type
- Article
- Keywords
- HOMOLOGOUS RECOMBINATION ; PHOSPHORYLATION ; CHECKPOINT ; PATHWAY
- ISSN
- 2372-3556
- Abstract
- RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
- Publisher
- Taylor and Francis Ltd.
- Related Researcher
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Kee, Younghoon
- Research Interests Genomic instability; DNA damage; DNA replication; DNA repair; Protein ubiquitination; Genome stability; DNA damage repair; Ubiquitin and proteolysis; tumor suppressive mechanisms
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- Appears in Collections:
- Department of New Biology Genomic Instability Lab 1. Journal Articles
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