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RAD51 wrestles with SUMO

Title
RAD51 wrestles with SUMO
Author(s)
Kee, YounghoonLee, Jung-HeeYou, Ho Jin
Issued Date
2022-12
Citation
Molecular and Cellular Oncology, v.9, no.1
Type
Article
Author Keywords
RAD51SUMO
Keywords
HOMOLOGOUS RECOMBINATIONPHOSPHORYLATIONCHECKPOINTPATHWAY
ISSN
2372-3556
Abstract
RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
URI
http://hdl.handle.net/20.500.11750/16523
DOI
10.1080/23723556.2022.2054263
Publisher
Taylor and Francis Ltd.
Related Researcher
  • 기영훈 Kee, Younghoon 뉴바이올로지학과
  • Research Interests Genomic instability; DNA damage; DNA replication; DNA repair; Protein ubiquitination; Genome stability; DNA damage repair; Ubiquitin and proteolysis; tumor suppressive mechanisms
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Department of New Biology Genomic Instability Lab 1. Journal Articles

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