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Single-Molecule Imaging of Membrane Proteins on Vascular Endothelial Cells

Title
Single-Molecule Imaging of Membrane Proteins on Vascular Endothelial Cells
Author(s)
Park, JiseongJin, SiwooJang, JuheeSeo, Daeha
Issued Date
2023-01
Citation
Journal of Lipid and Atherosclerosis, v.12, no.1, pp.58 - 72
Type
Article
Author Keywords
Vascular endotheliumMembrane proteinTranscytosisSingle molecule imagingOptical imaging
ISSN
2287-2892
Abstract
Transporting substances such as gases, nutrients, waste, and cells is the primary function of blood vessels. Vascular cells use membrane proteins to perform crucial endothelial functions, including molecular transport, immune cell infiltration, and angiogenesis. A thorough understanding of these membrane receptors from a clinical perspective is warranted to gain insights into the pathogenesis of vascular diseases and to develop effective methods for drug delivery through the vascular endothelium. This review summarizes state-of-the-art single-molecule imaging techniques, such as super-resolution microscopy, single-molecule tracking, and protein–protein interaction analysis, for observing and studying membrane proteins. Furthermore, recent single-molecule studies of membrane proteins such as cadherins, integrins, caveolins, transferrin receptors, vesicle-associated protein-1, and vascular endothelial growth factor receptor are discussed. © 2023 The Korean Society of Lipid and Atherosclerosis.
URI
http://hdl.handle.net/20.500.11750/17508
DOI
10.12997/jla.2023.12.1.58
Publisher
Korean Society of Lipid and Atherosclerosis
Related Researcher
  • 서대하 Seo, Daeha 화학물리학과
  • Research Interests Synthetic Chemistry of Nanomaterials; Biophysics; Cell biology
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Appears in Collections:
Department of Physics and Chemistry SMALL LAB(Single Molecule Approaches to ceLL Lab) 1. Journal Articles

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