Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun Hee G. | - |
dc.contributor.author | Kwak, Soo Heon | - |
dc.contributor.author | Hwang, Dae Hee | - |
dc.contributor.author | Yi, Eu Gene C. | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Koo, Bo Kyung | - |
dc.contributor.author | Kim, Kristine M. | - |
dc.date.available | 2017-07-05T08:47:18Z | - |
dc.date.created | 2017-04-20 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2307 | - |
dc.description.abstract | Background: The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects. Therefore, we aimed to investigate whether age affects the levels of these two antibodies in nondiabetic subjects. Methods: EEF1A1-AAb and UBE2L3-AAb levels in nondiabetic control subjects (n=150) and T1DM subjects (n=101) in various ranges of age (18 to 69 years) were measured using an enzyme-linked immunosorbent assay. The cutoffpoint for the presence of each autoantibody was determined based on control subjects using the formula: [mean absorbance+3×standard deviation]. Results: In nondiabetic subjects, there were no significant correlations between age and EEF1A1-AAb and UBE2L3-AAb levels. However, there was wide variation in EEF1A1-AAb and UBE2L3-AAb levels among control subjects < 40 years old; the prevalence of both EEF1A1-AAb and UBE2L3-AAb in these subjects was 4.4%. When using cutoffpoints determined from the control subjects < 40 years old, the prevalence of both autoantibodies in T1DM subjects was decreased (EEFA1-AAb, 15.8% to 8.9%; UBE2L3-AAb, 10.9% to 7.9%) when compared to the prevalence using the cutoffderived from the totals for control subjects. Conclusion: There was no association between age and EEF1A1-AAb or UBE2L3-AAb levels in nondiabetic subjects. However, the wide variation in EEF1A1-AAb and UBE2L3-AAb levels apparent among the control subjects < 40 years old should be taken into consideration when determining the cutoffreference range for the diagnosis of T1DM. © 2016 Korean Diabetes Association. | - |
dc.language | English | - |
dc.publisher | Korean Diabetes Association | - |
dc.title | The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 alpha 1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/dmj.2016.40.2.154 | - |
dc.identifier.wosid | 000388076600008 | - |
dc.identifier.scopusid | 2-s2.0-84964793157 | - |
dc.identifier.bibliographicCitation | Diabetes & Metabolism Journal, v.40, no.2, pp.154 - 160 | - |
dc.identifier.kciid | ART002100883 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Autoantibodies | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | type 1 | - |
dc.subject.keywordAuthor | Eukaryote translation elongation factor 1 alpha 1 autoantibody | - |
dc.subject.keywordAuthor | Ubiquitin-conjugating enzyme 2L3 autoantibody | - |
dc.subject.keywordPlus | GLUTAMIC-ACID DECARBOXYLASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | GAD | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.citation.endPage | 160 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 154 | - |
dc.citation.title | Diabetes & Metabolism Journal | - |
dc.citation.volume | 40 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.type.docType | Article | - |