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Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64
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- Title
- Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64
- Issued Date
- 2015-11
- Citation
- ACS Medicinal Chemistry Letters, v.6, no.11, pp.1162 - 1166
- Type
- Article
- Author Keywords
- Bifunctional chelator ; propylene cross bridge ; phosphonate pendant arms ; radiopharmaceuticals
- Keywords
- Radiopharmaceuticals ; STABILITY ; ACID ; Article ; Bifunctional Chelator ; BIOLOGICAL EVALUATION ; Chelating Agent ; COPPER ; Copper 64 ; Copper Complex ; COPPER(II) COMPLEXES ; Cyclic Potentiometry ; Drug Synthesis ; Electron Spin Resonance ; emISSION-TOMOGRAPHY ; High Performance Liquid Chromatography ; INERTNESS ; Ion Exchange Chromatography ; Ligand ; Paraformaldehyde ; Phosphonate Pendant Arms ; Phosphonic ACID Derivative ; Priority Journal ; Propylene ; Propylene Cross Bridge
- ISSN
- 1948-5875
- Abstract
-
A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A). © 2015 American Chemical Society.
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- Publisher
- American Chemical Society
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