Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Dong Hoon | - |
dc.contributor.author | Choi, Mina | - |
dc.contributor.author | Chang, Soyoung | - |
dc.contributor.author | Lee, Min Young | - |
dc.contributor.author | Lee, Doo Jae | - |
dc.contributor.author | Choi, Kyungsun | - |
dc.contributor.author | Park, Junseong | - |
dc.contributor.author | Han, Eun Chun | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kwon, Kihwan | - |
dc.contributor.author | Jo, Hanjoong | - |
dc.contributor.author | Choi, Chulhee | - |
dc.contributor.author | Kang, Sang Won | - |
dc.date.available | 2017-07-05T08:49:10Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2336 | - |
dc.description.abstract | Neointimal hyperplasia of vascular smooth muscle cells (VSMC) plays a critical role in atherosclerotic plaque formation and in-stent restenosis, but the underlying mechanisms are still incompletely understood. We performed a proteomics study to identify novel signaling molecules organizing the VSMC hyperplasia. The differential proteomics analysis in a balloon-induced injury model of rat carotid artery revealed that the expressions of 44 proteins are changed within 3 days post injury. The combination of cellular function assays and a protein network analysis further demonstrated that 27 out of 44 proteins constitute key signaling networks orchestrating the phenotypic change of VSMC from contractile to epitheliallike synthetic. Among the list of proteins, the in vivo validation specifically revealed that six proteins (Rab15, ITR, OLR1, PDHβ, PTPε) are positive regulators for VSMC hyperplasia. In particular, the OLR1 played dual roles in the VSMC hyperplasia by directly mediating oxidized LDL-induced monocyte adhesion via NF-êB activation and by assisting the PDGFinduced proliferation/migration. Importantly, OLR1 and PDGFRβ were associated in close proximity in the plasma membrane. Thus, this study elicits the protein network organizing the phenotypic change of VSMC in the vascular injury diseases such as atherosclerosis and discovers OLR1 as a novel molecular link between the proliferative and inflammatory responses of VSMCs. © 2015 Kang et al. | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.title | Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0133845 | - |
dc.identifier.scopusid | 2-s2.0-84942902672 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.10, no.8 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Animal Model | - |
dc.subject.keywordPlus | Animal Tissue | - |
dc.subject.keywordPlus | Artery Intima Proliferation | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | Carotid Artery Injury | - |
dc.subject.keywordPlus | Cell Adhesion | - |
dc.subject.keywordPlus | Cell Membrane | - |
dc.subject.keywordPlus | Cell Migration | - |
dc.subject.keywordPlus | Cell Proliferation | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | CORONARY ANGIOPLASTY | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | Human | - |
dc.subject.keywordPlus | Human Cell | - |
dc.subject.keywordPlus | Immunoglobulin Enhancer Binding Protein | - |
dc.subject.keywordPlus | Inflammation | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | Intimal Thickness Related Receptor | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | Monocyte | - |
dc.subject.keywordPlus | NEOINTIMAL GROWTH | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Oxidized Low Density Lipoprotein | - |
dc.subject.keywordPlus | Oxidized Low Density Lipoprotein Receptor 1 | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHENOTYPIC PLASTICITY | - |
dc.subject.keywordPlus | Platelet Derived Growth Factor Beta Receptor | - |
dc.subject.keywordPlus | Protein DNA Interaction | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Protein Protein Interaction | - |
dc.subject.keywordPlus | Protein Tyrosine Phosphatase Epsilon | - |
dc.subject.keywordPlus | Proteomics | - |
dc.subject.keywordPlus | Pyruvate Dehydrogenase | - |
dc.subject.keywordPlus | Pyruvate Dehydrogenase Beta | - |
dc.subject.keywordPlus | Rab Protein | - |
dc.subject.keywordPlus | Rab15 Protein | - |
dc.subject.keywordPlus | Rat | - |
dc.subject.keywordPlus | RAT CAROTID-ARTERY | - |
dc.subject.keywordPlus | Regulator Protein | - |
dc.subject.keywordPlus | STENOSIS | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.subject.keywordPlus | Vascular Smooth Muscle Cell | - |
dc.citation.number | 8 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 10 | - |
10.1371_journal.pone.0133845.pdf
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