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dc.contributor.author Kang, Dong Hoon -
dc.contributor.author Choi, Mina -
dc.contributor.author Chang, Soyoung -
dc.contributor.author Lee, Min Young -
dc.contributor.author Lee, Doo Jae -
dc.contributor.author Choi, Kyungsun -
dc.contributor.author Park, Junseong -
dc.contributor.author Han, Eun Chun -
dc.contributor.author Hwang, Daehee -
dc.contributor.author Kwon, Kihwan -
dc.contributor.author Jo, Hanjoong -
dc.contributor.author Choi, Chulhee -
dc.contributor.author Kang, Sang Won -
dc.date.available 2017-07-05T08:49:10Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-08 -
dc.identifier.issn 1932-6203 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2336 -
dc.description.abstract Neointimal hyperplasia of vascular smooth muscle cells (VSMC) plays a critical role in atherosclerotic plaque formation and in-stent restenosis, but the underlying mechanisms are still incompletely understood. We performed a proteomics study to identify novel signaling molecules organizing the VSMC hyperplasia. The differential proteomics analysis in a balloon-induced injury model of rat carotid artery revealed that the expressions of 44 proteins are changed within 3 days post injury. The combination of cellular function assays and a protein network analysis further demonstrated that 27 out of 44 proteins constitute key signaling networks orchestrating the phenotypic change of VSMC from contractile to epitheliallike synthetic. Among the list of proteins, the in vivo validation specifically revealed that six proteins (Rab15, ITR, OLR1, PDHβ, PTPε) are positive regulators for VSMC hyperplasia. In particular, the OLR1 played dual roles in the VSMC hyperplasia by directly mediating oxidized LDL-induced monocyte adhesion via NF-êB activation and by assisting the PDGFinduced proliferation/migration. Importantly, OLR1 and PDGFRβ were associated in close proximity in the plasma membrane. Thus, this study elicits the protein network organizing the phenotypic change of VSMC in the vascular injury diseases such as atherosclerosis and discovers OLR1 as a novel molecular link between the proliferative and inflammatory responses of VSMCs. © 2015 Kang et al. -
dc.language English -
dc.publisher Public Library of Science -
dc.title Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response -
dc.type Article -
dc.identifier.doi 10.1371/journal.pone.0133845 -
dc.identifier.scopusid 2-s2.0-84942902672 -
dc.identifier.bibliographicCitation PLoS ONE, v.10, no.8 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordPlus Animal Experiment -
dc.subject.keywordPlus Animal Model -
dc.subject.keywordPlus Animal Tissue -
dc.subject.keywordPlus Artery Intima Proliferation -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus ATHEROSCLEROSIS -
dc.subject.keywordPlus Carotid Artery Injury -
dc.subject.keywordPlus Cell Adhesion -
dc.subject.keywordPlus Cell Membrane -
dc.subject.keywordPlus Cell Migration -
dc.subject.keywordPlus Cell Proliferation -
dc.subject.keywordPlus Controlled Study -
dc.subject.keywordPlus CORONARY ANGIOPLASTY -
dc.subject.keywordPlus GROWTH-FACTOR -
dc.subject.keywordPlus Human -
dc.subject.keywordPlus Human Cell -
dc.subject.keywordPlus Immunoglobulin Enhancer Binding Protein -
dc.subject.keywordPlus Inflammation -
dc.subject.keywordPlus INHIBITION -
dc.subject.keywordPlus INJURY -
dc.subject.keywordPlus Intimal Thickness Related Receptor -
dc.subject.keywordPlus Male -
dc.subject.keywordPlus MICE LACKING -
dc.subject.keywordPlus Monocyte -
dc.subject.keywordPlus NEOINTIMAL GROWTH -
dc.subject.keywordPlus Nonhuman -
dc.subject.keywordPlus Oxidized Low Density Lipoprotein -
dc.subject.keywordPlus Oxidized Low Density Lipoprotein Receptor 1 -
dc.subject.keywordPlus PATHWAY -
dc.subject.keywordPlus PHENOTYPIC PLASTICITY -
dc.subject.keywordPlus Platelet Derived Growth Factor Beta Receptor -
dc.subject.keywordPlus Protein DNA Interaction -
dc.subject.keywordPlus Protein Expression -
dc.subject.keywordPlus Protein Protein Interaction -
dc.subject.keywordPlus Protein Tyrosine Phosphatase Epsilon -
dc.subject.keywordPlus Proteomics -
dc.subject.keywordPlus Pyruvate Dehydrogenase -
dc.subject.keywordPlus Pyruvate Dehydrogenase Beta -
dc.subject.keywordPlus Rab Protein -
dc.subject.keywordPlus Rab15 Protein -
dc.subject.keywordPlus Rat -
dc.subject.keywordPlus RAT CAROTID-ARTERY -
dc.subject.keywordPlus Regulator Protein -
dc.subject.keywordPlus STENOSIS -
dc.subject.keywordPlus Unclassified Drug -
dc.subject.keywordPlus Vascular Smooth Muscle Cell -
dc.citation.number 8 -
dc.citation.title PLoS ONE -
dc.citation.volume 10 -
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Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

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