Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | You, Sungyong | - |
dc.contributor.author | Hyeon, Do Young | - |
dc.contributor.author | Kang, Byeongsoo | - |
dc.contributor.author | Kim, Hyerim | - |
dc.contributor.author | Park, Kyoung Mii | - |
dc.contributor.author | Han, Byungwoo | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.available | 2017-07-11T04:43:08Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1758-0463 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2604 | - |
dc.description.abstract | Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/ AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers. © The Author(s) 2015. Published by Oxford University Press. | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.title | Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/database/bav022 | - |
dc.identifier.scopusid | 2-s2.0-84943279476 | - |
dc.identifier.bibliographicCitation | Database: the Journal of Biological Databases and Curation, v.2015 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | PROTEIN INTERACTIONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | ENCYCLOPEDIA | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | AIMP2/P38 | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GENES | - |
dc.citation.title | Database: the Journal of Biological Databases and Curation | - |
dc.citation.volume | 2015 | - |
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