Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Bhin, Jinhyuk | - |
dc.contributor.author | Jeong, Hoe-Su | - |
dc.contributor.author | Kim, Jong Soo | - |
dc.contributor.author | Shin, Jeong Oh | - |
dc.contributor.author | Hong, Ki Sung | - |
dc.contributor.author | Jung, Han-Sung | - |
dc.contributor.author | Kim, Changhoon | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kim, Kye-Seong | - |
dc.date.available | 2017-07-11T05:45:24Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2839 | - |
dc.description.abstract | Non-coding microRNAs (miRNAs) regulate the translation of target messenger RNAs (mRNAs) involved in the growth and development of a variety of cells, including primordial germ cells (PGCs) which play an essential role in germ cell development. However, the target mRNAs and the regulatory networks influenced by miRNAs in PGCs remain unc lear. Here, we demonstrate a novel miRNAs control PGC development through targeting mRNAs involved in various cellular pathways. We reveal the PGC-enriched expression patterns of nine miRNAs, including miR-10b, -18a, -93, - 106b, -126-3p, -127, -181a, -181b, and -301, using miRNA expression analysis along with mRNA microarray analysi sin PGCs, embryonic gonads, and postnatal testes. These miRNAs are highly expressed in PGCs, as demonstrated by Northern blotting, miRNA in situ hybridization assay, and miRNA qPCR analysis. This integrative study utilizing mRNA microarray analysis and miRNA target prediction demonstrates the regulatory networks through whic h these miRNAs regulate their potential target genes during PGC development. The elucidated networks of miRNAs disclose a coordinated molecular mechanism by which these miRNAs regulate distinct cellular pathways in PGCs that determine germ cell development. © The Korean Society for Molecular and Cellular Biology. All rights reserved. | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | PGC-Enriched miRNAs Control Germ Cell Development | - |
dc.type | Article | - |
dc.identifier.doi | 10.14348/molcells.2015.0146 | - |
dc.identifier.scopusid | 2-s2.0-84950291931 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, v.38, no.10, pp.895 - 903 | - |
dc.subject.keywordAuthor | bioinformatic analysis | - |
dc.subject.keywordAuthor | in situ hybridization | - |
dc.subject.keywordAuthor | male primordial germ cells | - |
dc.subject.keywordAuthor | microarray | - |
dc.subject.keywordAuthor | miRNAs | - |
dc.subject.keywordPlus | Animal Tissue | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Bioinformatic Analysis | - |
dc.subject.keywordPlus | Cell Adhesion | - |
dc.subject.keywordPlus | Cell Cycle | - |
dc.subject.keywordPlus | Cell Differentiation | - |
dc.subject.keywordPlus | Cell Proliferation | - |
dc.subject.keywordPlus | Cell Transport | - |
dc.subject.keywordPlus | Cellular Distribution | - |
dc.subject.keywordPlus | Chromosome 1 | - |
dc.subject.keywordPlus | Comparative Study | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | Gene Expression | - |
dc.subject.keywordPlus | Gene Expression Profiling | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | In Situ Hybridization | - |
dc.subject.keywordPlus | Intracellular Signaling | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Male Primordial Germ Cells | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Microarray | - |
dc.subject.keywordPlus | Microarray Analysis | - |
dc.subject.keywordPlus | Microrna | - |
dc.subject.keywordPlus | Microrna 106B | - |
dc.subject.keywordPlus | Microrna 10B | - |
dc.subject.keywordPlus | Microrna 126 3P | - |
dc.subject.keywordPlus | Microrna 127 | - |
dc.subject.keywordPlus | Microrna 18A | - |
dc.subject.keywordPlus | Microrna 18B | - |
dc.subject.keywordPlus | Microrna 301 | - |
dc.subject.keywordPlus | Microrna 93 | - |
dc.subject.keywordPlus | MICRORNA TARGETS | - |
dc.subject.keywordPlus | miRNAs | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Northern Blotting | - |
dc.subject.keywordPlus | Polymerase Chain Reaction | - |
dc.subject.keywordPlus | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | Primordial Germ Cell | - |
dc.subject.keywordPlus | Protein Degradation | - |
dc.subject.keywordPlus | REGULATORY MODULES | - |
dc.subject.keywordPlus | Reverse Transcription Polymerase Chain Reaction | - |
dc.subject.keywordPlus | RNA Processing | - |
dc.subject.keywordPlus | SMALL RNAS | - |
dc.subject.keywordPlus | SPERMATOGENESIS | - |
dc.subject.keywordPlus | STem-CELLS | - |
dc.subject.keywordPlus | Transcription Regulation | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.citation.endPage | 903 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 895 | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.volume | 38 | - |
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