Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Rah, Jong-Cheol | - |
dc.contributor.author | Feng, Linqing | - |
dc.contributor.author | Druckmann, Shaul | - |
dc.contributor.author | Lee, Hojin | - |
dc.contributor.author | Kim, Jinhyun | - |
dc.date.available | 2017-07-11T05:57:36Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1662-5129 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2892 | - |
dc.description.abstract | Mapping mammalian synaptic connectivity has long been an important goal of neuroscience because knowing how neurons and brain areas are connected underpins an understanding of brain function. Meeting this goal requires advanced techniques with single synapse resolution and large-scale capacity, especially at multiple scales tethering the meso- and micro-scale connectome. Among several advanced LM-based connectome technologies, Array Tomography (AT) and mammalian GFP-Reconstitution Across Synaptic Partners (mGRASP) can provide relatively high-throughput mapping synaptic connectivity at multiple scales. AT- and mGRASP-assisted circuit mapping (ATing and mGRASPing), combined with techniques such as retrograde virus, brain clearing techniques, and activity indicators will help unlock the secrets of complex neural circuits. Here, we discuss these useful new tools to enable mapping of brain circuits at multiple scales, some functional implications of spatial synaptic distribution, and future challenges and directions of these endeavors. © 2015 Rah, Feng, Druckmann, Lee and Kim. | - |
dc.publisher | Frontiers Research Foundation | - |
dc.title | From a meso- to micro-scale connectome: array tomography and mGRASP | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fnana.2015.00078 | - |
dc.identifier.scopusid | 2-s2.0-84935863487 | - |
dc.identifier.bibliographicCitation | Frontiers in Neuroanatomy, v.9, no.June | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | connectome | - |
dc.subject.keywordAuthor | mGRASP | - |
dc.subject.keywordAuthor | array tomography | - |
dc.subject.keywordAuthor | 3D atlasing | - |
dc.subject.keywordAuthor | multiple scales | - |
dc.subject.keywordPlus | 3D Atlasing | - |
dc.subject.keywordPlus | Array Tomography | - |
dc.subject.keywordPlus | Brain Mapping | - |
dc.subject.keywordPlus | Brain Tomography | - |
dc.subject.keywordPlus | Connectome | - |
dc.subject.keywordPlus | Dendritic Excitability | - |
dc.subject.keywordPlus | ELECTRON-MICROSCOPY | - |
dc.subject.keywordPlus | Functional Assessment | - |
dc.subject.keywordPlus | Gfp Reconstitution Across Synaptic Partner | - |
dc.subject.keywordPlus | Human | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MAMMALIAN SYNAPTIC CONNECTIVITY | - |
dc.subject.keywordPlus | mGRASP | - |
dc.subject.keywordPlus | MOUSE-BRAIN | - |
dc.subject.keywordPlus | Multiple Scales | - |
dc.subject.keywordPlus | Nerve Cell Network | - |
dc.subject.keywordPlus | Neural Circuits | - |
dc.subject.keywordPlus | NEURONAL CIRCUIT RECONSTRUCTION | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Photostimulation | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Proteomics | - |
dc.subject.keywordPlus | PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | Review | - |
dc.subject.keywordPlus | Spatial Analysis | - |
dc.subject.keywordPlus | VESICULAR GLUTAMATE TRANSPORTER-1 | - |
dc.subject.keywordPlus | VISUAL CORTICAL-NEURONS | - |
dc.citation.number | June | - |
dc.citation.title | Frontiers in Neuroanatomy | - |
dc.citation.volume | 9 | - |