Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Eunjeong | - |
dc.contributor.author | Park, Sungjun | - |
dc.contributor.author | Choi, Nahyun | - |
dc.contributor.author | Lee, Jieon | - |
dc.contributor.author | Yoe, Jeehyun | - |
dc.contributor.author | Kim, Soeun | - |
dc.contributor.author | Jung, Hoe-Yune | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Fryer, John D. | - |
dc.contributor.author | Zoghbi, Huda Y. | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Lee, Yoontae | - |
dc.date.available | 2017-07-11T06:00:41Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2936 | - |
dc.description.abstract | Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L-/-) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines. We discovered that several drug metabolism and BA transporter genes were down-regulated in Cic-L-/- liver, and that BA was increased in the liver and serum whereas bile was decreased within the gallbladder of Cic-L-/- mice. We also found that levels of proinflammatory cytokine genes were up-regulated in Cic-L-/- liver. Consistent with this finding, levels of hepatic transcriptional regulators, such as hepatic nuclear factor 1 alpha (HNF1 alpha), CCAAT/enhancer-binding protein beta (C/EBP beta), forkhead box protein A2 (FOXA2), and retinoid X receptor alpha (RXR alpha), were markedly decreased in Cic-L-/- mice. Moreover, induction of tumor necrosis factor alpha (Tnf alpha) expression and decrease in the levels of FOXA2, C/EBP beta, and RXRa were found in Cic-L-/- liver before BA was accumulated, suggesting that inflammation might be the cause for the cholestasis in Cic-L-/- mice. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Deficiency of Capicua disrupts bile acid homeostasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/srep08272 | - |
dc.identifier.scopusid | 2-s2.0-84943376843 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.5 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | CONSTITUTIVE ANDROSTANE RECEPTOR | - |
dc.subject.keywordPlus | ENRICHED TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | PREGNANE-X-RECEPTOR | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | REPRESSOR | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | CAR | - |
dc.subject.keywordPlus | PXR | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 5 | - |