Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Pandya, Darpan N. | - |
dc.contributor.author | Bhatt, Nikunj | - |
dc.contributor.author | An, Gwang Il | - |
dc.contributor.author | Ha, Yeong Su | - |
dc.contributor.author | Soni, Nisarg | - |
dc.contributor.author | Lee, Hochun | - |
dc.contributor.author | Lee, Yong Jin | - |
dc.contributor.author | Kim, Jung Young | - |
dc.contributor.author | Lee, Woonghee | - |
dc.contributor.author | Ahn, Heesu | - |
dc.contributor.author | Yoo, Jeongsoo | - |
dc.date.available | 2017-07-11T06:18:20Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2014-09-11 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3036 | - |
dc.description.abstract | The first macrocyclic bifunctional chelator incorporating propylene cross-bridge was efficiently synthesized from cyclam in seven steps. After the introduction of an extra functional group for facile conjugation onto the propylene cross-bridge, the two carboxylic acid pendants could contribute to strong coordination of Cu(II) ions, leading to a robust Cu complex. The cyclic RGD peptide conjugate of PCB-TE2A-NCS was prepared and successfully radiolabeled with 64Cu ion. The radiolabeled peptide conjugate was evaluated in vivo through a biodistribution study and animal PET imaging to demonstrate high tumor uptake with low background. © 2014 American Chemical Society. | - |
dc.publisher | American Chemical Society | - |
dc.title | Propylene Cross-Bridged Macrocyclic Bifunctional Chelator: A New Design for Facile Bioconjugation and Robust Cu-64 Complex Stability | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jm500348z | - |
dc.identifier.scopusid | 2-s2.0-84907211109 | - |
dc.identifier.bibliographicCitation | Journal of Medicinal Chemistry, v.57, no.17, pp.7234 - 7243 | - |
dc.subject.keywordPlus | IN-VIVO BEHAVIOR | - |
dc.subject.keywordPlus | CYCLIC RGD PEPTIDE | - |
dc.subject.keywordPlus | TETRAAZAMACROCYCLIC COMPLEXES | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | COPPER-COMPLEXES | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | RADIOPHARMACEUTICALS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.citation.endPage | 7243 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 7234 | - |
dc.citation.title | Journal of Medicinal Chemistry | - |
dc.citation.volume | 57 | - |
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