Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pandya, DN[Pandya, Darpan N.] | ko |
dc.contributor.author | Dale, AV[Dale, Ajit V.] | ko |
dc.contributor.author | Kim, JY[Kim, Jung Young] | ko |
dc.contributor.author | Lee, H[Lee, Hochun] | ko |
dc.contributor.author | Ha, YS[Ha, Yeong Su] | ko |
dc.contributor.author | An, GI[An, Gwang Il] | ko |
dc.contributor.author | Yoo, J[Yoo, Jeongsoo] | ko |
dc.date.available | 2017-07-11T06:56:50Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | Bioconjugate Chemistry, v.23, no.3, pp.330 - 335 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3385 | - |
dc.description.abstract | Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable 64Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable 64Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with 64Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the 64Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation. © 2012 American Chemical Society. | - |
dc.publisher | American Chemical Society | - |
dc.subject | Acetic Acid | - |
dc.subject | Animals | - |
dc.subject | Bridged Compound | - |
dc.subject | Chelating Agent | - |
dc.subject | Chelating Agents | - |
dc.subject | Chemical Reaction Kinetics | - |
dc.subject | Chromatography, High Pressure Liquid | - |
dc.subject | Complex Formation | - |
dc.subject | Conjugate | - |
dc.subject | Copper 64 | - |
dc.subject | Copper Complex | - |
dc.subject | Copper Radioisotopes | - |
dc.subject | Cyclam Derivative | - |
dc.subject | Ethylene | - |
dc.subject | Isotope Labeling | - |
dc.subject | Macrocyclic Compound | - |
dc.subject | Macrocyclic Compounds | - |
dc.subject | Molecular Stability | - |
dc.subject | Propylene | - |
dc.subject | Quantitative Analysis | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Reduction | - |
dc.subject | Spectrophotometry, Ultraviolet | - |
dc.subject | Synthesis | - |
dc.title | New Macrobicyclic Chelator for the Development of Ultrastable Cu-64-Radiolabeled Bioconjugate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/bc200539t | - |
dc.identifier.wosid | 000301700200003 | - |
dc.identifier.scopusid | 2-s2.0-84863338426 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Pandya, DN[Pandya, Darpan N.] | - |
dc.contributor.nonIdAuthor | Dale, AV[Dale, Ajit V.] | - |
dc.contributor.nonIdAuthor | Kim, JY[Kim, Jung Young] | - |
dc.contributor.nonIdAuthor | Ha, YS[Ha, Yeong Su] | - |
dc.contributor.nonIdAuthor | An, GI[An, Gwang Il] | - |
dc.contributor.nonIdAuthor | Yoo, J[Yoo, Jeongsoo] | - |
dc.identifier.citationVolume | 23 | - |
dc.identifier.citationNumber | 3 | - |
dc.identifier.citationStartPage | 330 | - |
dc.identifier.citationEndPage | 335 | - |
dc.identifier.citationTitle | Bioconjugate Chemistry | - |
dc.type.journalArticle | Article | - |
dc.contributor.affiliatedAuthor | Lee, H[Lee, Hochun] | - |
There are no files associated with this item.