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Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion
- Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion
- Lee, HJ[Lee, Hyun Ju]; Lee, SG[Lee, Se Guen]; Oh, EJ[Oh, Eun Jung]; Chung, HY[Chung, Ho Yun]; Han, SI[Han, Sang Ik]; Kim, EJ[Kim, Eun Jung]; Seo, SY[Seo, Song Yi]; Do Ghim, H[Do Ghim, Han]; Yeum, JH[Yeum, Jeong Hyun]; Choi, JH[Choi, Jin Hyun]
- DGIST Authors
- Lee, HJ[Lee, Hyun Ju]; Lee, SG[Lee, Se Guen]
- Issue Date
- Colloids and Surfaces B: Biointerfaces, 88(1), 505-511
- Article Type
- Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH 4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH 4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion. © 2011 Elsevier B.V.
- ELSEVIER SCIENCE BV
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- Magnet-Controlled Materials Research Group1. Journal Articles
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