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dc.contributor.authorJi, Yonghwanko
dc.contributor.authorLee, Hyuck Jinko
dc.contributor.authorKim, Minjeongko
dc.contributor.authorNam, Geewooko
dc.contributor.authorLee, Shin Jung C.ko
dc.contributor.authorCho, Jaeheungko
dc.contributor.authorPark, Cheol-Minko
dc.contributor.authorLim, Mi Heeko
dc.date.available2017-08-10T08:11:44Z-
dc.date.created2017-08-09-
dc.date.issued2017-06-05-
dc.identifier.citationInorganic Chemistry, v.56, no.11, pp.6695 - 6705-
dc.identifier.issn0020-1669-
dc.identifier.urihttp://hdl.handle.net/20.500.11750/4157-
dc.description.abstractThe complexity of Alzheimer’s disease (AD) stems from the inter-relation of multiple pathological factors upon initiation and progression of the disease. To identify the involvement of metal-bound amyloid-β (metal-Aβ) aggregation in AD pathology, among the pathogenic features found in the AD-affected brain, small molecules as chemical tools capable of controlling metal-Aβ aggregation were developed. Herein, we report a new class of 2,2′-bipyridine (bpy) derivatives (1-4) rationally designed to be chemical modulators toward metal-Aβ aggregation over metal-free Aβ analogue. The bpy derivatives were constructed through a rational design strategy employing straightforward structural variations onto the backbone of a metal chelator, bpy: (i) incorporation of an Aβ interacting moiety; (ii) introduction of a methyl group at different positions. The newly prepared bpy derivatives were observed to bind to metal ions [i.e., Cu(II) and Zn(II)] and interact with metal-Aβ over metal-free Aβ to varying degrees. Distinguishable from bpy, the bpy derivatives (1-3) were indicated to noticeably modulate the aggregation pathways of Cu(II)-Aβ and Zn(II)-Aβ over metal-free Aβ. Overall, our studies of the bpy derivatives demonstrate that the alteration of metal binding properties as well as the installation of an Aβ interacting capability onto a metal chelating framework, devised via the rational structure-based design, were able to achieve evident modulating reactivity against metal-Aβ aggregation. Obviating the need for complicated structures, our design approach, presented in this work, could be appropriately utilized for inventing small molecules as chemical tools for studying desired metal-related targets in biological systems. © 2017 American Chemical Society.-
dc.publisherAmerican Chemical Society-
dc.subject2,2&apos-
dc.subjectDipyridyl-
dc.subjectA Beta-
dc.subjectAbsorption-
dc.subjectAlzheimer&apos-
dc.subjects Disease (AD)-
dc.subjectComplexes-
dc.subjectCoordination-
dc.subjectMechanisms-
dc.subjectPeptide-
dc.subjectSmall Molecules-
dc.subjectTarget-
dc.titleStrategic Design of 2,2 '-Bipyridine Derivatives to Modulate Metal Amyloid-beta Aggregation-
dc.typeArticle-
dc.identifier.doi10.1021/acs.inorgchem.7b00782-
dc.identifier.wosid000402950600073-
dc.identifier.scopusid2-s2.0-85020272501-
dc.type.localArticle(Overseas)-
dc.type.rimsART-
dc.description.journalClass1-
dc.contributor.localauthorCho, Jaeheung-
dc.contributor.nonIdAuthorJi, Yonghwan-
dc.contributor.nonIdAuthorLee, Hyuck Jin-
dc.contributor.nonIdAuthorKim, Minjeong-
dc.contributor.nonIdAuthorNam, Geewoo-
dc.contributor.nonIdAuthorLee, Shin Jung C.-
dc.contributor.nonIdAuthorPark, Cheol-Min-
dc.contributor.nonIdAuthorLim, Mi Hee-
dc.identifier.citationVolume56-
dc.identifier.citationNumber11-
dc.identifier.citationStartPage6695-
dc.identifier.citationEndPage6705-
dc.identifier.citationTitleInorganic Chemistry-
dc.type.journalArticleArticle-


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