Cited 0 time in webofscience Cited 0 time in scopus

Nitrated Proteome in Human Embryonic Stem Cells

Title
Nitrated Proteome in Human Embryonic Stem Cells
Authors
Kang, Jeong WonHwang, DaeheeKim, Kwang Pyo
DGIST Authors
Kang, Jeong Won; Hwang, Daehee; Kim, Kwang Pyo
Issue Date
2016-12
Citation
Mass Spectrometry Letters, 7(4), 85-90
Type
Article
Article Type
Review
Author Keywords
Tyrosine nitrationNitrotyrosine enrichmentLC-MS/MSProteomicsEmbryonic stem cells
Keywords
MASS-SPECTROMETRIC IDENTIFICATIONTYROSINE NITRATIONNITRIC-OXIDESELECTIVE ENRICHMENTPHOSPHORYLATIONPEPTIDESDIFFERENTIATIONPROTEINSDYNAMICSDISEASES
ISSN
2233-4203
Abstract
Post-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs. © 2016, Korean Society for Mass Spectrometry. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/4295
DOI
10.5478/MSL.2016.7.4.85
Publisher
Korean Society for Mass Spectrometry
Files:
There are no files associated with this item.
Collection:
Department of New BiologySystems Biology and Medicine Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE