Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyeongkyu | - |
dc.contributor.author | Boo, Kyungjin | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Oh, Se Kyu | - |
dc.contributor.author | Kim, Hyunkyung | - |
dc.contributor.author | Jeon, Yoon | - |
dc.contributor.author | Bhin, Jinhyuk | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Lee, Jun-Su | - |
dc.contributor.author | Im, Seung-Soon | - |
dc.contributor.author | Yoon, Seul Gi | - |
dc.contributor.author | Kim, Il Yong | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Fang, Sungsoon | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.available | 2017-09-11T09:28:00Z | - |
dc.date.created | 2017-09-11 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4447 | - |
dc.description.abstract | The retinoic acid receptor-related orphan receptor-α (RORα) is an important regulator of various biological processes, including cerebellum development, circadian rhythm and cancer. Here, we show that hepatic RORα controls lipid homeostasis by negatively regulating transcriptional activity of peroxisome proliferators-activated receptor-γ (PPARγ) that mediates hepatic lipid metabolism. Liver-specific Rorα-deficient mice develop hepatic steatosis, obesity and insulin resistance when challenged with a high-fat diet (HFD). Global transcriptome analysis reveals that liver-specific deletion of Rorα leads to the dysregulation of PPARγ signaling and increases hepatic glucose and lipid metabolism. RORα specifically binds and recruits histone deacetylase 3 (HDAC3) to PPARγ target promoters for the transcriptional repression of PPARγ. PPARγ antagonism restores metabolic homeostasis in HFD-fed liver-specific Rorα deficient mice. Our data indicate that RORα has a pivotal role in the regulation of hepatic lipid homeostasis. Therapeutic strategies designed to modulate RORα activity may be beneficial for the treatment of metabolic disorders. © 2017 The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | ROR alpha controls hepatic lipid homeostasis via negative regulation of PPAR gamma transcriptional network | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-017-00215-1 | - |
dc.identifier.scopusid | 2-s2.0-85026528725 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.8, no.1 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | Diet Induced Obesity | - |
dc.subject.keywordPlus | Expression | - |
dc.subject.keywordPlus | Fatty Liver | - |
dc.subject.keywordPlus | Insulin Resistance | - |
dc.subject.keywordPlus | Large Gene Lists | - |
dc.subject.keywordPlus | Metabolic Syndrome | - |
dc.subject.keywordPlus | Mus | - |
dc.subject.keywordPlus | Orphan Nuclear Receptors | - |
dc.subject.keywordPlus | Rev Erb | - |
dc.subject.keywordPlus | RNA Seq | - |
dc.subject.keywordPlus | Staggerer Mouse | - |
dc.citation.number | 1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 8 | - |
10.1038_s41467_017_00215_1.pdf
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