Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 곽준명 | - |
| dc.contributor.author | Bum Suk Kim | - |
| dc.date.accessioned | 2023-03-22T19:56:17Z | - |
| dc.date.available | 2023-03-22T19:56:17Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/45673 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000656597 | - |
| dc.description | Cellular plasticity, regeneration, reprogramming, drug tolerance, DTP, single-cell multiomics | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1.1 Cellular plasticity and single-cell multiomics 1 1.2 iPSC reprogramming 2 1.3 DTP (drug-tolerantpersister) in the cancer 3 1.4 Oncofetal signature & DTP 5 Ⅱ. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin 6 2.1 Introduction 6 2.2 Results 7 2.3 Discussion 11 2.4.Figures 13 2.5.Methods and materials 21 2.6. Acknowledgement 32 Ⅲ. Single-cell multi-omics analysis reveals distinct transcriptional and epigenetic signatures of transiently primed drug-naïve cancer cells leading to an epigenetically stable drug-tolerant state 33 3.1 Introduction 33 3.2 Results 34 3.3 Discussion 39 3.4.Figures 40 3.5.Methods and materials 54 3.6. Acknowledgement 59 Ⅳ. Conclusion 60 Ⅴ. Reference 61 요 약 문 75 |
- |
| dc.format.extent | 75 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment | - |
| dc.title.alternative | 단일세포멀티오믹스 분석기법을 이용한 생체왜 세포 리프로그래밍과 항암제 처리반응에서의 세포의 유연성에 대한 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000656597 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | Department of New Biology | - |
| dc.contributor.coadvisor | Jong Kyoung Kim | - |
| dc.date.awarded | 2023-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.ND 김44 202302 | - |
| dc.date.accepted | 2023-03-21 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | Cellular plasticity | - |
| dc.subject.keyword | regeneration | - |
| dc.subject.keyword | reprogramming | - |
| dc.subject.keyword | drug tolerance | - |
| dc.subject.keyword | DTP | - |
| dc.subject.keyword | single-cell multiomics | - |
| dc.contributor.affiliatedAuthor | Bum Suk Kim | - |
| dc.contributor.affiliatedAuthor | June M. Kwak | - |
| dc.contributor.affiliatedAuthor | Jong Kyoung Kim | - |
| dc.contributor.alternativeName | 김범석 | - |
| dc.contributor.alternativeName | June M. Kwak | - |
| dc.contributor.alternativeName | 김종경 | - |
| dc.rights.embargoReleaseDate | 2028-02-28 | - |
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