Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dan Bi | - |
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Jeong, Ju Hwan | - |
dc.contributor.author | Jang, Ui Soon | - |
dc.contributor.author | Jang, Yuyeon | - |
dc.contributor.author | Roh, Seokbeom | - |
dc.contributor.author | Jeon, Hyunbum | - |
dc.contributor.author | Kim, Eun Jeong | - |
dc.contributor.author | Han, Su Yeon | - |
dc.contributor.author | Maeng, Jin Young | - |
dc.contributor.author | Magez, Stefan | - |
dc.contributor.author | Radwanska, Magdalena | - |
dc.contributor.author | Mun, Ji Young | - |
dc.contributor.author | Jun, Hyun Sik | - |
dc.contributor.author | Lee, Gyudo | - |
dc.contributor.author | Song, Min-Suk | - |
dc.contributor.author | Lee, Hye-Ra | - |
dc.contributor.author | Chung, Mi Sook | - |
dc.contributor.author | Baek, Yun Hee | - |
dc.contributor.author | Kim, Kyung Hyun | - |
dc.date.accessioned | 2023-07-12T11:10:20Z | - |
dc.date.available | 2023-07-12T11:10:20Z | - |
dc.date.created | 2023-02-09 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/46124 | - |
dc.description.abstract | Recurrent spillovers of α- and β-coronaviruses (CoV) such as severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome-CoV, SARS-CoV-2, and possibly human CoV have caused serious morbidity and mortality worldwide. In this study, six receptor-binding domains (RBDs) derived from α- and β-CoV that are considered to have originated from animals and cross-infected humans were linked to a heterotrimeric scaffold, proliferating cell nuclear antigen (PCNA) subunits, PCNA1, PCNA2, and PCNA3. They assemble to create a stable mosaic multivalent nanoparticle, 6RBD-np, displaying a ring-shaped disk with six protruding antigens, like jewels in a crown. Prime-boost immunizations with 6RBD-np in mice induced significantly high Ab titers against RBD antigens derived from α- and β-CoV and increased interferon (IFN-γ) production, with full protection against the SARS-CoV-2 wild type and Delta challenges. The mosaic 6RBD-np has the potential to induce intergenus cross-reactivity and to be developed as a pan-CoV vaccine against future CoV spillovers. Copyright © 2023 the Author(s). | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2208425120 | - |
dc.identifier.scopusid | 2-s2.0-85146905390 | - |
dc.identifier.bibliographicCitation | Proceedings of the National Academy of Sciences of the United States of America, v.120, no.4 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | receptor-binding domain | - |
dc.subject.keywordAuthor | mosaic multivalent antigens | - |
dc.subject.keywordAuthor | immune response | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | spike | - |
dc.subject.keywordPlus | RECEPTOR-BINDING DOMAIN | - |
dc.subject.keywordPlus | HETEROTRIMERIC PCNA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | ELICITATION | - |
dc.subject.keywordPlus | VACCINES | - |
dc.citation.number | 4 | - |
dc.citation.title | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.citation.volume | 120 | - |
There are no files associated with this item.