Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Khan, Tunazzina Zaman | - |
dc.contributor.author | Newaj, Shekh Md | - |
dc.contributor.author | Rahman, Ashikur | - |
dc.contributor.author | Tabassum, Rahnuma | - |
dc.contributor.author | Tasnim, Khandaker Nujhat | - |
dc.contributor.author | Reza, Hasan Mahmud | - |
dc.contributor.author | Reza, Md. Selim | - |
dc.contributor.author | Hong, Seonki | - |
dc.contributor.author | Sharker, Shazid Md. | - |
dc.date.accessioned | 2023-12-18T14:40:20Z | - |
dc.date.available | 2023-12-18T14:40:20Z | - |
dc.date.created | 2023-10-27 | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2633-5409 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/46677 | - |
dc.description.abstract | In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm3). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care. © 2023 The Author(s). | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d3ma00375b | - |
dc.identifier.scopusid | 2-s2.0-85174283371 | - |
dc.identifier.bibliographicCitation | Materials Advances, v.4, no.21, pp.5175 - 5183 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CARBON NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | GRAPHENE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | NANOPLATFORM | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MOUSE | - |
dc.citation.endPage | 5183 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 5175 | - |
dc.citation.title | Materials Advances | - |
dc.citation.volume | 4 | - |