A high throughput screening platform to rejuvenate skeletal muscle function via electrical stimulation

Abstract

Sarcopenia is the disease owing to loss of muscle tissue as a natural part of the aging process and it has not yet developed drugs. Unfortunately, although exercise is the only way to treat sarcopenia, it is sometimes difficult for elderly people to exercise by various inconvenient body conditions. While many studies have been done to apply electrical stimulation (ES) as an alternative intervention of exercise, there are still unmet demands to investigate the effect of precise and systemic ES for skeletal muscle cells (skMC) as well as to explore the behavior of aged skMC. As such, we developed a novel ES-based high throughput screening platform to quantitatively search the ES effect for skMC. Using this platform, we could see the possibility to improve the functions of old skMC cells via ES. © 2019 CBMS-0001.