Title

Determining the biophysical properties of indolicidin-derived antimicrobial peptide

Alternative Title

인돌리시딘 유래 항균 펩타이드의 생물물리학적 특성에 대한 연구

DGIST Authors

Jihyun Kim ; Chang Hoon Nam ; Jin Hae Kim

Advisor

남창훈

Co-Advisor(s)

Jin Hae Kim

Issued Date

2024

Awarded Date

2024-02-01

Citation

Jihyun Kim. (2024). Determining the biophysical properties of indolicidin-derived antimicrobial peptide. doi: 10.22677/THESIS.200000725083

Type

Thesis

Description

Antimicrobial peptide;Amphipathicity;Structural rigidity;Membrane selectivity;Mode of action

Table Of Contents

Ⅰ. Introduction 1
Ⅱ. Materials and methods 2
2.1 Peptide synthesis 2
2.2 Optical Diffraction Tomography (ODT) assay 3
2.3 Nuclear Magnetic Resonance (NMR) 3
2.4 Simulation 6
Ⅲ. Results 7
3.1 Tomographic analysis of E. coli 7
3.2 Tomographic analysis of sRBCs 7
3.3 NMR Experiments and Structural Model Calculation 11
3.4 Simulation 15
Ⅳ. Discussion 20
References 23

URI

http://hdl.handle.net/20.500.11750/48062
http://dgist.dcollection.net/common/orgView/200000725083

DOI

10.22677/THESIS.200000725083

Degree

Master

Department

Department of New Biology

Publisher

DGIST

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