Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이재민 | - |
| dc.contributor.author | Hyejin Lee | - |
| dc.date.accessioned | 2024-02-29T21:01:35Z | - |
| dc.date.available | 2024-02-29T21:01:35Z | - |
| dc.date.issued | 2024 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/48064 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000723580 | - |
| dc.description | Dual agonist;GPR40;GLP-1;Type 2 diabetes | - |
| dc.description.tableofcontents | List of Contents Abstract · i List of contents · ii Ⅰ. Introductions 1 1.1 Glucose homeostasis of Type 2 diabetes (T2D) · 1 1.2 Partial GPR40 agonist, TAK-875 (Fasiglifam) · 2 1.3 GLP-1 Receptor (GLP-1R) agonist, Exendin-4 · 4 1.4 Objective 5 II. Materials and Methods 7 2.1 Materials 7 2.2 Methods 8 III. Results 13 3.1 The activation of GPR40 and GLP-1R increased insulin secretion. 13 3.2 Chronic dual GPR40/GLP-1R agonist injection ameliorates hyperglycemia in diabetic db/db mice. 15 3.3 Chronic administration of the dual GPR40/GLP-1R agonist elevates the portion of insulin-producing β-cells in the db/db islets. · 16 3.4 Chronic injection of dual GPR40/GLP-1R agonist did not induce abnormal liver function. 17 3.5 sExn-4 and dual GPR40/GLP-1R agonist improved insulin signaling in differentiated muscle (C2C12) and adipose (3T3-L1) cells. 18 IV. Discussion 37 Reference · 39 요약문 42 |
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| dc.format.extent | 42 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Dual GPR40/GLP-1R agonist ameliorates hyperglycemia of type 2 diabetes. | - |
| dc.title.alternative | G 단백질결합수용체 40 (GPR40)/글루카곤 유사 펩타이드 1 수용체 (GLP-1R) 이중 작용제에 의한 제 2 형 당뇨병 개선. | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000723580 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of New Biology | - |
| dc.contributor.coadvisor | Kyeong-min Lee | - |
| dc.date.awarded | 2024-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.NM이94 202402 | - |
| dc.date.accepted | 2024-01-30 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | Dual agonist | - |
| dc.subject.keyword | GPR40 | - |
| dc.subject.keyword | GLP-1 | - |
| dc.subject.keyword | Type 2 diabetes | - |
| dc.contributor.affiliatedAuthor | Hyejin Lee | - |
| dc.contributor.affiliatedAuthor | Jaemin Lee | - |
| dc.contributor.affiliatedAuthor | Kyeong-min Lee | - |
| dc.contributor.alternativeName | 이혜진 | - |
| dc.contributor.alternativeName | Jaemin Lee | - |
| dc.contributor.alternativeName | 이경민 | - |
| dc.rights.embargoReleaseDate | 2029-02-28 | - |
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