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dc.contributor.authorBin, Bum-Hoko
dc.contributor.authorBhin, Jinhyukko
dc.contributor.authorTakaishi, Mikiroko
dc.contributor.authorToyoshima, Koh-eiko
dc.contributor.authorKawamata, Saekoko
dc.contributor.authorIto, Kanako
dc.contributor.authorHara, Takafumiko
dc.contributor.authorWatanabe, Takashiko
dc.contributor.authorIrie, Tarouko
dc.contributor.authorTakagishi, Teruhisako
dc.contributor.authorLee, Su-Hyonko
dc.contributor.authorJung, Haeng-Sunko
dc.contributor.authorRho, Sangchulko
dc.contributor.authorSeo, Juyeonko
dc.contributor.authorChoi, Dong-Hwako
dc.contributor.authorHwang, Dae Heeko
dc.contributor.authorKoseki, Haruhikoko
dc.contributor.authorOhara, Osamuko
dc.contributor.authorSano, Shigetoshiko
dc.contributor.authorTsuji, Takashiko
dc.contributor.authorMishima, Kenjiko
dc.contributor.authorFukada, Toshiyukiko
dc.date.accessioned2018-01-11T13:01:23Z-
dc.date.available2018-01-11T13:01:23Z-
dc.date.created2018-01-01-
dc.date.created2018-01-01-
dc.date.issued2017-11-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, v.114, no.46, pp.12243 - 12248-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/20.500.11750/4854-
dc.description.abstractSkin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Both ZIP10 and p63 are significantly increased during epidermal development, in which ZIP10-mediated zinc influx promotes p63 transactivation. Collectively, these results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10–zinc–p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis. © 2017, National Academy of Sciences. All rights reserved.-
dc.languageEnglish-
dc.publisherNational Academy of Sciences-
dc.subjectACRODERMATITIS-ENTEROPATHICA-
dc.subjectSTEM-CELLS-
dc.subjectGENE-EXPRESSION-
dc.subjectHAIR FOLLICLE-
dc.subjectDNA-BINDING-
dc.subjectRNA-SEQ-
dc.subjectP63-
dc.subjectDIFFERENTIATION-
dc.subjectSKIN-
dc.subjectPROLIFERATION-
dc.titleRequirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis-
dc.typeArticle-
dc.identifier.doi10.1073/pnas.1710726114-
dc.identifier.wosid000415173300063-
dc.identifier.scopusid2-s2.0-85033717861-
dc.type.localArticle(Overseas)-
dc.type.rimsART-
dc.description.journalClass1-
dc.contributor.localauthorHwang, Dae Hee-
dc.contributor.nonIdAuthorBin, Bum-Ho-
dc.contributor.nonIdAuthorBhin, Jinhyuk-
dc.contributor.nonIdAuthorTakaishi, Mikiro-
dc.contributor.nonIdAuthorToyoshima, Koh-ei-
dc.contributor.nonIdAuthorKawamata, Saeko-
dc.contributor.nonIdAuthorIto, Kana-
dc.contributor.nonIdAuthorHara, Takafumi-
dc.contributor.nonIdAuthorWatanabe, Takashi-
dc.contributor.nonIdAuthorIrie, Tarou-
dc.contributor.nonIdAuthorTakagishi, Teruhisa-
dc.contributor.nonIdAuthorLee, Su-Hyon-
dc.contributor.nonIdAuthorJung, Haeng-Sun-
dc.contributor.nonIdAuthorRho, Sangchul-
dc.contributor.nonIdAuthorSeo, Juyeon-
dc.contributor.nonIdAuthorChoi, Dong-Hwa-
dc.contributor.nonIdAuthorKoseki, Haruhiko-
dc.contributor.nonIdAuthorOhara, Osamu-
dc.contributor.nonIdAuthorSano, Shigetoshi-
dc.contributor.nonIdAuthorTsuji, Takashi-
dc.contributor.nonIdAuthorMishima, Kenji-
dc.contributor.nonIdAuthorFukada, Toshiyuki-
dc.identifier.citationVolume114-
dc.identifier.citationNumber46-
dc.identifier.citationStartPage12243-
dc.identifier.citationEndPage12248-
dc.identifier.citationTitleProceedings of the National Academy of Sciences of the United States of America-
dc.type.journalArticleArticle-
dc.description.isOpenAccessN-


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