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In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

Title
In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels
Authors
Noshadi, ImanHong, SeonkiSullivan, Kelly E.Shirzaei Sani, EhsanPortillo-Lara, RobertoTamayol, AliShin, Su RyonGao, Albert E.Stoppel, Whitney L.Black, Lauren D. IIIKhademhosseini, AliAnnabi, Nasim
DGIST Authors
Hong, Seonki
Issue Date
2017
Citation
Biomaterials Science, 5(10), 2093-2105
Type
Article
Article Type
Article
Keywords
BiocompatibilityBiological materialsBiomimetic materialsBiomimeticsCardiologyCharacterizationDiseasesHistologyLightPore sizeSwellingTissueTissue engineeringBiomimetic hydrogelsCardio-vascular diseaseCross-linked gelatinsCross-linked hydrogelsEngineered materialsMechanical characterizationsMyocardial InfarctionUltraviolet lightsHydrogels
ISSN
2047-4830
Abstract
Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5-56 kPa by changing the concentrations of the initiator, co-initiator and co-monomer in the precursor formulation. In addition, the average pore sizes (26-103 μm) and swelling ratios (7-13%) were also shown to be tunable by varying the hydrogel formulation. In vitro studies showed that visible light crosslinked GelMA hydrogels supported the growth and function of primary cardiomyocytes (CMs). In addition, the engineered materials were shown to be biocompatible in vivo, and could be successfully delivered to the heart after myocardial infarction in an animal model to promote tissue healing. The developed visible light crosslinked hydrogel could be used for the repair of various soft tissues such as the myocardium and for the treatment of cardiovascular diseases with enhanced therapeutic functionality. ©2017 The Royal Society of Chemistry.
URI
http://hdl.handle.net/20.500.11750/5025
DOI
10.1039/c7bm00110j
Publisher
Royal Society of Chemistry
Related Researcher
  • Author Hong, Seonki Biomaterials & Biointerface Engineering Laboratory
  • Research Interests
Files:
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Collection:
Department of Emerging Materials ScienceBiomaterials & Biointerface Engineering Laboratory1. Journal Articles


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