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Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Title
Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors
Authors
Yoon, JunghyoZirpel, Nuriye KorkmazPark, Hyun-JiHan, SewoonHwang, Kyung HoonShin, JisooCho, Seung-WooNam, Chang-HoonChung, Seok
DGIST Authors
Nam, Chang-Hoon
Issue Date
2016-01-21
Citation
Advanced Healthcare Materials, 5(2), 205-212
Type
Article
Article Type
Article
Keywords
AngiogenesisBacteriophagesCollagenGrowth Factors, VEGF
ISSN
2192-2640
Abstract
Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI
http://hdl.handle.net/20.500.11750/5124
DOI
10.1002/adhm.201500534
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Nam, Chang-Hoon  
  • Research Interests Protein Engineering; History and Philosophy of Science; Scientific Art; Biomaterial Development (Tissue Engineering) with modified bacteriophage; Bio Sensor Development
Files:
There are no files associated with this item.
Collection:
School of Undergraduate Studies1. Journal Articles


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