Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Chul | ko |
dc.contributor.author | Kim, Eunjoo | ko |
dc.contributor.author | Jeong, Sang Won | ko |
dc.contributor.author | Lee, Se Guen | ko |
dc.contributor.author | Lee, Sung Jun | ko |
dc.contributor.author | Lee, Seung Woo | ko |
dc.date.accessioned | 2018-01-25T01:10:50Z | - |
dc.date.available | 2018-01-25T01:10:50Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | Macromolecular Research, v.23, no.2, pp.196 - 204 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5207 | - |
dc.description.abstract | Gemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG)2-Cyt-(PBC)2) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteine-poly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG)2-Cyt-(PBC)2 formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG)2-Cyt-(PBC)2 micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.[Figure not available: see fulltext.] © 2015, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht. | - |
dc.publisher | Polymer Society of Korea | - |
dc.subject | Amino Acids | - |
dc.subject | Controlled Drug Delivery | - |
dc.subject | Covalent Bonds | - |
dc.subject | Critical Micelle Concentration (CMC) | - |
dc.subject | Cystines | - |
dc.subject | Cytotoxicity | - |
dc.subject | Disulfide-Thiol Exchange | - |
dc.subject | Disulfide-Thiol Exchanges | - |
dc.subject | Drug Delivery | - |
dc.subject | Drug Delivery System | - |
dc.subject | Drug Products | - |
dc.subject | Gemini Surfactant | - |
dc.subject | Gemini Surfactants | - |
dc.subject | GSH Concentrations | - |
dc.subject | Intracellular Compartments | - |
dc.subject | Loading | - |
dc.subject | Micelles | - |
dc.subject | Microscopic Observations | - |
dc.subject | Peptides | - |
dc.subject | Polyethylene Glycols | - |
dc.subject | Polymers | - |
dc.subject | Polyols | - |
dc.subject | Polypeptide | - |
dc.subject | Polypeptides | - |
dc.subject | Stimuli-Sensitive Polymers | - |
dc.subject | Sulfur Compounds | - |
dc.title | Glutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13233-015-3030-4 | - |
dc.identifier.wosid | 000350362900012 | - |
dc.identifier.scopusid | 2-s2.0-84925488116 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.kciid | ART001962689 | - |
dc.contributor.nonIdAuthor | Lee, Seung Woo | - |
dc.identifier.citationVolume | 23 | - |
dc.identifier.citationNumber | 2 | - |
dc.identifier.citationStartPage | 196 | - |
dc.identifier.citationEndPage | 204 | - |
dc.identifier.citationTitle | Macromolecular Research | - |
dc.type.journalArticle | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Chul | - |
dc.contributor.affiliatedAuthor | Kim, Eunjoo | - |
dc.contributor.affiliatedAuthor | Jeong, Sang Won | - |
dc.contributor.affiliatedAuthor | Lee, Se Guen | - |
dc.contributor.affiliatedAuthor | Lee, Sung Jun | - |
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