Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, Su-Ho | - |
dc.contributor.author | Kim, Jung-Hee | - |
dc.contributor.author | Lee, Dong-Hun | - |
dc.contributor.author | Kang, Jeong-Woo | - |
dc.contributor.author | Song, Hyuk-Hwan | - |
dc.contributor.author | Oh, Sei-Ryang | - |
dc.contributor.author | Yoon, Do-Young | - |
dc.date.accessioned | 2018-01-25T01:12:59Z | - |
dc.date.available | 2018-01-25T01:12:59Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0300-9084 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5295 | - |
dc.description.abstract | Matrix metalloproteinase 9 (MMP-9) and interleukin-8 (IL-8) play major roles in tumor progression and invasion of breast cancer cells. The present study was undertaken to investigate the inhibitory mechanism of cell invasion by luteolin 8-C-β-fucopyranoside (named as LU8C-FP), a C-glycosylflavone, in human breast cancer cells. We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells. LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-κB. TPA-induced phosphorylation of ERK 1/2 was suppressed by LU8C-FP, whereas JNK and p38 MAPK phosphorylation were unaffected. In addition, LU8C-FP blocked the ERK 1/2 pathways following expression of MMP-9 and IL-8. These results suggest LU8C-FP may function to suppress invasion of breast cancer cells through the ERK/AP-1 and ERK/NF-κB signaling cascades. © 2013 Elsevier Masson SAS. All rights reserved. | - |
dc.publisher | Elsevier | - |
dc.title | Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappa B signaling in MCF-7 breast cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biochi.2013.07.021 | - |
dc.identifier.scopusid | 2-s2.0-84885047264 | - |
dc.identifier.bibliographicCitation | Biochimie, v.95, no.11, pp.2082 - 2090 | - |
dc.subject.keywordAuthor | Cancer invasion | - |
dc.subject.keywordAuthor | Flavonoid | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | IL-8 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordPlus | FLAVONE C-GLYCOSIDES | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE-9 EXPRESSION | - |
dc.subject.keywordPlus | ADENOCARCINOMA CELLS | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INTERLEUKIN-8 | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.citation.endPage | 2090 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2082 | - |
dc.citation.title | Biochimie | - |
dc.citation.volume | 95 | - |
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